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Late Pregnancy Exposures to Disinfection By-products and Growth-Related Birth Outcomes

Toxicologic studies have demonstrated associations between growth-related birth outcomes and exposure to high concentrations of disinfection by-products (DBPs), including specific tri-halomethane (THM) and haloacetic acid (HAA) chemical subspecies. Few prior investigations of DBPs have evaluated exp...

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Autores principales: Hinckley, Alison F., Bachand, Annette M., Reif, John S.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314926/
https://www.ncbi.nlm.nih.gov/pubmed/16330369
http://dx.doi.org/10.1289/ehp.8282
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author Hinckley, Alison F.
Bachand, Annette M.
Reif, John S.
author_facet Hinckley, Alison F.
Bachand, Annette M.
Reif, John S.
author_sort Hinckley, Alison F.
collection PubMed
description Toxicologic studies have demonstrated associations between growth-related birth outcomes and exposure to high concentrations of disinfection by-products (DBPs), including specific tri-halomethane (THM) and haloacetic acid (HAA) chemical subspecies. Few prior investigations of DBPs have evaluated exposure during the third trimester of pregnancy, the time period of gestation when fetal growth may be most sensitive to environmental influences. We conducted a retrospective cohort study to examine the effects of exposure to THMs and HAAs during the third trimester and during individual weeks and months of late gestation on the risks for term low birth weight, intrauterine growth retardation, and very preterm and preterm births. The study population (n = 48,119) included all live births and fetal deaths occurring from January 1998 through March 2003 to women whose residence was served by one of three community water treatment facilities. We found evidence of associations between exposure to specific HAAs and term low birth weight as well as intrauterine growth retardation and for exposure to the five regulated HAAs (HAA5) and term low birth weight. Our findings suggest a critical window of exposure with respect to fetal development during weeks 33–40 for the effects of dibromoacetic acid and during weeks 37–40 for the effects of dichloroacetic acid. Adjustment for potential confounders did not affect the conclusions.
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spelling pubmed-13149262006-01-02 Late Pregnancy Exposures to Disinfection By-products and Growth-Related Birth Outcomes Hinckley, Alison F. Bachand, Annette M. Reif, John S. Environ Health Perspect Research Toxicologic studies have demonstrated associations between growth-related birth outcomes and exposure to high concentrations of disinfection by-products (DBPs), including specific tri-halomethane (THM) and haloacetic acid (HAA) chemical subspecies. Few prior investigations of DBPs have evaluated exposure during the third trimester of pregnancy, the time period of gestation when fetal growth may be most sensitive to environmental influences. We conducted a retrospective cohort study to examine the effects of exposure to THMs and HAAs during the third trimester and during individual weeks and months of late gestation on the risks for term low birth weight, intrauterine growth retardation, and very preterm and preterm births. The study population (n = 48,119) included all live births and fetal deaths occurring from January 1998 through March 2003 to women whose residence was served by one of three community water treatment facilities. We found evidence of associations between exposure to specific HAAs and term low birth weight as well as intrauterine growth retardation and for exposure to the five regulated HAAs (HAA5) and term low birth weight. Our findings suggest a critical window of exposure with respect to fetal development during weeks 33–40 for the effects of dibromoacetic acid and during weeks 37–40 for the effects of dichloroacetic acid. Adjustment for potential confounders did not affect the conclusions. National Institute of Environmental Health Sciences 2005-12 2005-08-17 /pmc/articles/PMC1314926/ /pubmed/16330369 http://dx.doi.org/10.1289/ehp.8282 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Hinckley, Alison F.
Bachand, Annette M.
Reif, John S.
Late Pregnancy Exposures to Disinfection By-products and Growth-Related Birth Outcomes
title Late Pregnancy Exposures to Disinfection By-products and Growth-Related Birth Outcomes
title_full Late Pregnancy Exposures to Disinfection By-products and Growth-Related Birth Outcomes
title_fullStr Late Pregnancy Exposures to Disinfection By-products and Growth-Related Birth Outcomes
title_full_unstemmed Late Pregnancy Exposures to Disinfection By-products and Growth-Related Birth Outcomes
title_short Late Pregnancy Exposures to Disinfection By-products and Growth-Related Birth Outcomes
title_sort late pregnancy exposures to disinfection by-products and growth-related birth outcomes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314926/
https://www.ncbi.nlm.nih.gov/pubmed/16330369
http://dx.doi.org/10.1289/ehp.8282
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