Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss

BACKGROUND: Vasospasm of the spiral modiolar artery (SMA) may cause ischemic stroke of the inner ear. Endothelin-1 (ET-1) induces a strong, long-lasting constriction of the SMA by increasing contractile apparatus Ca(2+ )sensitivity via Rho-kinase. We therefore tested several Rho-kinase inhibitors an...

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Detalles Bibliográficos
Autores principales: Scherer, Elias Q, Arnold, Wolfgang, Wangemann, Philine
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315339/
https://www.ncbi.nlm.nih.gov/pubmed/16316469
http://dx.doi.org/10.1186/1472-6815-5-10

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