Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P

Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in Molecular Pain (2005, 1:20), describes its potential role in feed-forward inh...

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Detalles Bibliográficos
Autores principales: Wu, Long-Jun, Xu, Hui, Ko, Shanelle W, Yoshimura, Megumu, Zhuo, Min
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315348/
https://www.ncbi.nlm.nih.gov/pubmed/16297242
http://dx.doi.org/10.1186/1744-8069-1-34
Descripción
Sumario:Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in Molecular Pain (2005, 1:20), describes its potential role in feed-forward inhibition in lamina V of the dorsal horn of the spinal cord. This inhibition seems to function through a direct excitation of GABAergic interneurons by substance P released from primary afferent fibers and has a distinct temporal phase of action from the well-described glutamate-dependent feed-forward inhibition. It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord.

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