Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P

Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in Molecular Pain (2005, 1:20), describes its potential role in feed-forward inh...

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Detalles Bibliográficos
Autores principales: Wu, Long-Jun, Xu, Hui, Ko, Shanelle W, Yoshimura, Megumu, Zhuo, Min
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315348/
https://www.ncbi.nlm.nih.gov/pubmed/16297242
http://dx.doi.org/10.1186/1744-8069-1-34
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author Wu, Long-Jun
Xu, Hui
Ko, Shanelle W
Yoshimura, Megumu
Zhuo, Min
author_facet Wu, Long-Jun
Xu, Hui
Ko, Shanelle W
Yoshimura, Megumu
Zhuo, Min
author_sort Wu, Long-Jun
collection PubMed
description Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in Molecular Pain (2005, 1:20), describes its potential role in feed-forward inhibition in lamina V of the dorsal horn of the spinal cord. This inhibition seems to function through a direct excitation of GABAergic interneurons by substance P released from primary afferent fibers and has a distinct temporal phase of action from the well-described glutamate-dependent feed-forward inhibition. It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord.
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spelling pubmed-13153482005-12-16 Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P Wu, Long-Jun Xu, Hui Ko, Shanelle W Yoshimura, Megumu Zhuo, Min Mol Pain Commentary Substance P (SP) is a neuropeptide well known for its contribution to pain transmission in the spinal cord, however, less is known about the possible modulatory effects of SP. A new study by Gu and colleagues, published in Molecular Pain (2005, 1:20), describes its potential role in feed-forward inhibition in lamina V of the dorsal horn of the spinal cord. This inhibition seems to function through a direct excitation of GABAergic interneurons by substance P released from primary afferent fibers and has a distinct temporal phase of action from the well-described glutamate-dependent feed-forward inhibition. It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord. BioMed Central 2005-11-18 /pmc/articles/PMC1315348/ /pubmed/16297242 http://dx.doi.org/10.1186/1744-8069-1-34 Text en Copyright © 2005 Wu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Wu, Long-Jun
Xu, Hui
Ko, Shanelle W
Yoshimura, Megumu
Zhuo, Min
Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
title Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
title_full Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
title_fullStr Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
title_full_unstemmed Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
title_short Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
title_sort feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance p
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315348/
https://www.ncbi.nlm.nih.gov/pubmed/16297242
http://dx.doi.org/10.1186/1744-8069-1-34
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