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Synthesis and hybridization studies of oligonucleotides containing 1-(2-deoxy-2-α-C-hydroxymethyl-β-d-ribofuranosyl)thymine (2′-α-hm-dT)

We report the first investigation of oligoribonucleotides containing a few 1-(2-deoxy-2-α-C-hydroxymethyl-β-d-ribofuranosyl)thymine units (or 2′-hm-dT, abbreviated in this work as ‘H’). Both the 2′-CH(2)O-phosphoramidite and 3′-O-phosphoramidite derivatives of H were synthesized and incorporated int...

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Detalles Bibliográficos
Autores principales: Peng, Chang Geng, Damha, Masad J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1322267/
https://www.ncbi.nlm.nih.gov/pubmed/16377780
http://dx.doi.org/10.1093/nar/gki1003

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