Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice

BACKGROUND: Analysis of an allelic series of point mutations in a gene, generated by N-ethyl-N-nitrosourea (ENU) mutagenesis, is a valuable method for discovering the full scope of its biological function. Here we present an efficient gene-driven approach for identifying ENU-induced point mutations...

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Detalles Bibliográficos
Autores principales: Michaud, Edward J, Culiat, Cymbeline T, Klebig, Mitchell L, Barker, Paul E, Cain, KT, Carpenter, Debra J, Easter, Lori L, Foster, Carmen M, Gardner, Alysyn W, Guo, ZY, Houser, Kay J, Hughes, Lori A, Kerley, Marilyn K, Liu, Zhaowei, Olszewski, Robert E, Pinn, Irina, Shaw, Ginger D, Shinpock, Sarah G, Wymore, Ann M, Rinchik, Eugene M, Johnson, Dabney K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325271/
https://www.ncbi.nlm.nih.gov/pubmed/16300676
http://dx.doi.org/10.1186/1471-2164-6-164

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