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Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer
BACKGROUND: Zoledronic acid is very widely used in patients with metastatic bone disease and osteoporosis. Only one case of bilateral uveitis was recently reported related to its use. CASE PRESENTATION: We report the first case of severe unilateral anterior uveitis in a patient with breast cancer an...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326210/ https://www.ncbi.nlm.nih.gov/pubmed/16332258 http://dx.doi.org/10.1186/1471-2407-5-156 |
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author | El Saghir, Nagi S Otrock, Zaher K Bleik, Jamal H |
author_facet | El Saghir, Nagi S Otrock, Zaher K Bleik, Jamal H |
author_sort | El Saghir, Nagi S |
collection | PubMed |
description | BACKGROUND: Zoledronic acid is very widely used in patients with metastatic bone disease and osteoporosis. Only one case of bilateral uveitis was recently reported related to its use. CASE PRESENTATION: We report the first case of severe unilateral anterior uveitis in a patient with breast cancer and an intraocular lens. Following zoledronic acid infusion, the patient developed severe and dramatic right eye pain with decreased visual acuity within 24 hours and was found to have a fibrinous anterior uveitis of moderate severity The patient was treated with topical prednisone and atropine eyedrops and recovered slowly over several months. CONCLUSION: Internists, oncologists, endocrinologists, and ophtalmologists should be aware of uveitis as a possible complication of zoledronic acid therapy. Patients should be instructed to report immediately to their physicians and treatment with topical prednisone and atropine eyedrops should be instituted immediately at the onset of symptoms. This report documents anterior uveitis as a complication of zoledronic acid therapy. This reaction could be an idiosyncratic one but further research may shed more light on the etiology. |
format | Text |
id | pubmed-1326210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-13262102006-01-12 Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer El Saghir, Nagi S Otrock, Zaher K Bleik, Jamal H BMC Cancer Case Report BACKGROUND: Zoledronic acid is very widely used in patients with metastatic bone disease and osteoporosis. Only one case of bilateral uveitis was recently reported related to its use. CASE PRESENTATION: We report the first case of severe unilateral anterior uveitis in a patient with breast cancer and an intraocular lens. Following zoledronic acid infusion, the patient developed severe and dramatic right eye pain with decreased visual acuity within 24 hours and was found to have a fibrinous anterior uveitis of moderate severity The patient was treated with topical prednisone and atropine eyedrops and recovered slowly over several months. CONCLUSION: Internists, oncologists, endocrinologists, and ophtalmologists should be aware of uveitis as a possible complication of zoledronic acid therapy. Patients should be instructed to report immediately to their physicians and treatment with topical prednisone and atropine eyedrops should be instituted immediately at the onset of symptoms. This report documents anterior uveitis as a complication of zoledronic acid therapy. This reaction could be an idiosyncratic one but further research may shed more light on the etiology. BioMed Central 2005-12-06 /pmc/articles/PMC1326210/ /pubmed/16332258 http://dx.doi.org/10.1186/1471-2407-5-156 Text en Copyright © 2005 El Saghir et al; licensee BioMed Central Ltd. |
spellingShingle | Case Report El Saghir, Nagi S Otrock, Zaher K Bleik, Jamal H Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer |
title | Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer |
title_full | Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer |
title_fullStr | Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer |
title_full_unstemmed | Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer |
title_short | Unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer |
title_sort | unilateral anterior uveitis complicating zoledronic acid therapy in breast cancer |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326210/ https://www.ncbi.nlm.nih.gov/pubmed/16332258 http://dx.doi.org/10.1186/1471-2407-5-156 |
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