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Linking uracil base excision repair and 5-fluorouracil toxicity in yeast

5-fluorouracil (5-FU) is a widely used anticancer drug that disrupts pyrimidine nucleotide pool balances and leads to uracil incorporation in DNA, which is then recognized and removed by the uracil base excision repair (BER) pathway. Using complementary biochemical and genetic approaches we have exa...

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Detalles Bibliográficos
Autores principales:	Seiple, Lauren, Jaruga, Pawel, Dizdaroglu, Miral, Stivers, James T.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2006
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326247/ https://www.ncbi.nlm.nih.gov/pubmed/16407331 http://dx.doi.org/10.1093/nar/gkj430

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