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Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
Exposure to manganese via inhalation has long been known to elicit neurotoxicity in adults, but little is known about possible consequences of exposure via drinking water. In this study, we report results of a cross-sectional investigation of intellectual function in 142 10-year-old children in Arai...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1332667/ https://www.ncbi.nlm.nih.gov/pubmed/16393669 http://dx.doi.org/10.1289/ehp.8030 |
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author | Wasserman, Gail A. Liu, Xinhua Parvez, Faruque Ahsan, Habibul Levy, Diane Factor-Litvak, Pam Kline, Jennie van Geen, Alexander Slavkovich, Vesna LoIacono, Nancy J. Cheng, Zhongqi Zheng, Yan Graziano, Joseph H. |
author_facet | Wasserman, Gail A. Liu, Xinhua Parvez, Faruque Ahsan, Habibul Levy, Diane Factor-Litvak, Pam Kline, Jennie van Geen, Alexander Slavkovich, Vesna LoIacono, Nancy J. Cheng, Zhongqi Zheng, Yan Graziano, Joseph H. |
author_sort | Wasserman, Gail A. |
collection | PubMed |
description | Exposure to manganese via inhalation has long been known to elicit neurotoxicity in adults, but little is known about possible consequences of exposure via drinking water. In this study, we report results of a cross-sectional investigation of intellectual function in 142 10-year-old children in Araihazar, Bangladesh, who had been consuming tube-well water with an average concentration of 793 μg Mn/L and 3 μg arsenic/L. Children and mothers came to our field clinic, where children received a medical examination in which weight, height, and head circumference were measured. Children’s intellectual function was assessed on tests drawn from the Wechsler Intelligence Scale for Children, version III, by summing weighted items across domains to create Verbal, Performance, and Full-Scale raw scores. Children provided urine specimens for measuring urinary As and creatinine and were asked to provide blood samples for measuring blood lead, As, Mn, and hemoglobin concentrations. After adjustment for sociodemographic covariates, water Mn was associated with reduced Full-Scale, Performance, and Verbal raw scores, in a dose–response fashion; the low level of As in water had no effect. In the United States, roughly 6% of domestic household wells have Mn concentrations that exceed 300 μg Mn/L, the current U.S. Environmental Protection Agency lifetime health advisory level. We conclude that in both Bangladesh and the United States, some children are at risk for Mn-induced neurotoxicity. |
format | Text |
id | pubmed-1332667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-13326672006-01-25 Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh Wasserman, Gail A. Liu, Xinhua Parvez, Faruque Ahsan, Habibul Levy, Diane Factor-Litvak, Pam Kline, Jennie van Geen, Alexander Slavkovich, Vesna LoIacono, Nancy J. Cheng, Zhongqi Zheng, Yan Graziano, Joseph H. Environ Health Perspect Research Exposure to manganese via inhalation has long been known to elicit neurotoxicity in adults, but little is known about possible consequences of exposure via drinking water. In this study, we report results of a cross-sectional investigation of intellectual function in 142 10-year-old children in Araihazar, Bangladesh, who had been consuming tube-well water with an average concentration of 793 μg Mn/L and 3 μg arsenic/L. Children and mothers came to our field clinic, where children received a medical examination in which weight, height, and head circumference were measured. Children’s intellectual function was assessed on tests drawn from the Wechsler Intelligence Scale for Children, version III, by summing weighted items across domains to create Verbal, Performance, and Full-Scale raw scores. Children provided urine specimens for measuring urinary As and creatinine and were asked to provide blood samples for measuring blood lead, As, Mn, and hemoglobin concentrations. After adjustment for sociodemographic covariates, water Mn was associated with reduced Full-Scale, Performance, and Verbal raw scores, in a dose–response fashion; the low level of As in water had no effect. In the United States, roughly 6% of domestic household wells have Mn concentrations that exceed 300 μg Mn/L, the current U.S. Environmental Protection Agency lifetime health advisory level. We conclude that in both Bangladesh and the United States, some children are at risk for Mn-induced neurotoxicity. National Institute of Environmental Health Sciences 2006-01 2005-08-09 /pmc/articles/PMC1332667/ /pubmed/16393669 http://dx.doi.org/10.1289/ehp.8030 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Wasserman, Gail A. Liu, Xinhua Parvez, Faruque Ahsan, Habibul Levy, Diane Factor-Litvak, Pam Kline, Jennie van Geen, Alexander Slavkovich, Vesna LoIacono, Nancy J. Cheng, Zhongqi Zheng, Yan Graziano, Joseph H. Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh |
title | Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh |
title_full | Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh |
title_fullStr | Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh |
title_full_unstemmed | Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh |
title_short | Water Manganese Exposure and Children’s Intellectual Function in Araihazar, Bangladesh |
title_sort | water manganese exposure and children’s intellectual function in araihazar, bangladesh |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1332667/ https://www.ncbi.nlm.nih.gov/pubmed/16393669 http://dx.doi.org/10.1289/ehp.8030 |
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