Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53–MDM2 Pathway

Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), a deubiquitylating enzyme of the ubiquitin-specific processing protease family, specifically deubiquitylates both p53 and MDM2, hence playing an important yet enigmatic role in the p53–MDM2 pathway. Here we demonstrate t...

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Detalles Bibliográficos
Autores principales: Hu, Min, Gu, Lichuan, Li, Muyang, Jeffrey, Philip D, Gu, Wei, Shi, Yigong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1334386/
https://www.ncbi.nlm.nih.gov/pubmed/16402859
http://dx.doi.org/10.1371/journal.pbio.0040027

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