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Potential risk factors for diabetic neuropathy: a case control study

BACKGROUND: Diabetes mellitus type II afflicts at least 2 million people in Iran. Neuropathy is one of the most common complications of diabetes and lowers the patient's quality of life. Since neuropathy often leads to ulceration and amputation, we have tried to elucidate the factors that can a...

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Autores principales: Booya, Fargol, Bandarian, Fatemeh, Larijani, Bagher, Pajouhi, Mohammad, Nooraei, Mahdi, Lotfi, Jamshid
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1343576/
https://www.ncbi.nlm.nih.gov/pubmed/16336693
http://dx.doi.org/10.1186/1471-2377-5-24
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author Booya, Fargol
Bandarian, Fatemeh
Larijani, Bagher
Pajouhi, Mohammad
Nooraei, Mahdi
Lotfi, Jamshid
author_facet Booya, Fargol
Bandarian, Fatemeh
Larijani, Bagher
Pajouhi, Mohammad
Nooraei, Mahdi
Lotfi, Jamshid
author_sort Booya, Fargol
collection PubMed
description BACKGROUND: Diabetes mellitus type II afflicts at least 2 million people in Iran. Neuropathy is one of the most common complications of diabetes and lowers the patient's quality of life. Since neuropathy often leads to ulceration and amputation, we have tried to elucidate the factors that can affect its progression. METHODS: In this case-control study, 110 diabetic patients were selected from the Shariati Hospital diabetes clinic. Michigan Neuropathic Diabetic Scoring (MNDS) was used to differentiate cases from controls. The diagnosis of neuropathy was confirmed by nerve conduction studies (nerve conduction velocity and electromyography). The multiple factors compared between the two groups included consumption of angiotensin converting enzyme inhibitors (ACEI), blood pressure, serum lipid level, sex, smoking, method of diabetes control and its quality. RESULTS: Statistically significant relationships were found between neuropathy and age, gender, quality of diabetes control and duration of disease (P values in the order: 0.04, 0.04, < 0.001 and 0.005). No correlation was found with any atherosclerosis risk factor (high BP, hyperlipidemia, cigarette smoking). CONCLUSION: In this study, hyperglycemia was the only modifiable risk factor for diabetic neuropathy. Glycemic control reduces the incidence of neuropathy, slows its progression and improves the diabetic patient's quality of life. More attention must be paid to elderly male diabetic patients with poor diabetes control with regard to regular foot examinations and more practical education.
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spelling pubmed-13435762006-01-21 Potential risk factors for diabetic neuropathy: a case control study Booya, Fargol Bandarian, Fatemeh Larijani, Bagher Pajouhi, Mohammad Nooraei, Mahdi Lotfi, Jamshid BMC Neurol Research Article BACKGROUND: Diabetes mellitus type II afflicts at least 2 million people in Iran. Neuropathy is one of the most common complications of diabetes and lowers the patient's quality of life. Since neuropathy often leads to ulceration and amputation, we have tried to elucidate the factors that can affect its progression. METHODS: In this case-control study, 110 diabetic patients were selected from the Shariati Hospital diabetes clinic. Michigan Neuropathic Diabetic Scoring (MNDS) was used to differentiate cases from controls. The diagnosis of neuropathy was confirmed by nerve conduction studies (nerve conduction velocity and electromyography). The multiple factors compared between the two groups included consumption of angiotensin converting enzyme inhibitors (ACEI), blood pressure, serum lipid level, sex, smoking, method of diabetes control and its quality. RESULTS: Statistically significant relationships were found between neuropathy and age, gender, quality of diabetes control and duration of disease (P values in the order: 0.04, 0.04, < 0.001 and 0.005). No correlation was found with any atherosclerosis risk factor (high BP, hyperlipidemia, cigarette smoking). CONCLUSION: In this study, hyperglycemia was the only modifiable risk factor for diabetic neuropathy. Glycemic control reduces the incidence of neuropathy, slows its progression and improves the diabetic patient's quality of life. More attention must be paid to elderly male diabetic patients with poor diabetes control with regard to regular foot examinations and more practical education. BioMed Central 2005-12-10 /pmc/articles/PMC1343576/ /pubmed/16336693 http://dx.doi.org/10.1186/1471-2377-5-24 Text en Copyright © 2005 Booya et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Booya, Fargol
Bandarian, Fatemeh
Larijani, Bagher
Pajouhi, Mohammad
Nooraei, Mahdi
Lotfi, Jamshid
Potential risk factors for diabetic neuropathy: a case control study
title Potential risk factors for diabetic neuropathy: a case control study
title_full Potential risk factors for diabetic neuropathy: a case control study
title_fullStr Potential risk factors for diabetic neuropathy: a case control study
title_full_unstemmed Potential risk factors for diabetic neuropathy: a case control study
title_short Potential risk factors for diabetic neuropathy: a case control study
title_sort potential risk factors for diabetic neuropathy: a case control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1343576/
https://www.ncbi.nlm.nih.gov/pubmed/16336693
http://dx.doi.org/10.1186/1471-2377-5-24
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