p21(WAF1 )expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells

BACKGROUND: p21(WAF1), implicated in the cell cycle control of both normal and malignant cells, can be induced by p53-dependent and independent mechanisms. In some cells, MEKs/ERKs regulate p21(WAF1 )transcriptionally, while in others they also affect the post-transcriptional processes. In myogenic...

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Detalles Bibliográficos
Autores principales: Ciccarelli, Carmela, Marampon, Francesco, Scoglio, Arianna, Mauro, Annunziata, Giacinti, Cristina, De Cesaris, Paola, Zani, Bianca M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1343585/
https://www.ncbi.nlm.nih.gov/pubmed/16351709
http://dx.doi.org/10.1186/1476-4598-4-41

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