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A short purification process for quantitative isolation of PrP(Sc) from naturally occurring and experimental transmissible spongiform encephalopathies

BACKGROUND: Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases affecting both humans and animals. They are associated with post-translational conversion of the normal cellular prion protein (PrP(C)) into a heat- and protease-resistant abnormal isoform (PrP(Sc)). Detectio...

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Detalles Bibliográficos
Autores principales:	Polymenidou, Magdalini, Verghese-Nikolakaki, Susan, Groschup, Martin, Chaplin, Melanie J, Stack, Mick J, Plaitakis, Andreas, Sklaviadis, Theodoros
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2002
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC134455/ https://www.ncbi.nlm.nih.gov/pubmed/12370086 http://dx.doi.org/10.1186/1471-2334-2-23

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