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Sequence- and structural-selective nucleic acid binding revealed by the melting of mixtures
A simple method for the detection of sequence- and structural-selective ligand binding to nucleic acids is described. The method is based on the commonly used thermal denaturation method in which ligand binding is registered as an elevation in the nucleic acid melting temperature (T(m)). The method...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1345701/ https://www.ncbi.nlm.nih.gov/pubmed/16432258 http://dx.doi.org/10.1093/nar/gnj012 |