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Argonaute—a database for gene regulation by mammalian microRNAs

MicroRNAs (miRNAs) constitute a recently discovered class of small non-coding RNAs that regulate expression of target genes either by decreasing the stability of the target mRNA or by translational inhibition. They are involved in diverse processes, including cellular differentiation, proliferation...

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Autores principales: Shahi, Priyanka, Loukianiouk, Serguei, Bohne-Lang, Andreas, Kenzelmann, Marc, Küffer, Stefan, Maertens, Sabine, Eils, Roland, Gröne, Herrmann-Josef, Gretz, Norbert, Brors, Benedikt
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347455/
https://www.ncbi.nlm.nih.gov/pubmed/16381827
http://dx.doi.org/10.1093/nar/gkj093
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author Shahi, Priyanka
Loukianiouk, Serguei
Bohne-Lang, Andreas
Kenzelmann, Marc
Küffer, Stefan
Maertens, Sabine
Eils, Roland
Gröne, Herrmann-Josef
Gretz, Norbert
Brors, Benedikt
author_facet Shahi, Priyanka
Loukianiouk, Serguei
Bohne-Lang, Andreas
Kenzelmann, Marc
Küffer, Stefan
Maertens, Sabine
Eils, Roland
Gröne, Herrmann-Josef
Gretz, Norbert
Brors, Benedikt
author_sort Shahi, Priyanka
collection PubMed
description MicroRNAs (miRNAs) constitute a recently discovered class of small non-coding RNAs that regulate expression of target genes either by decreasing the stability of the target mRNA or by translational inhibition. They are involved in diverse processes, including cellular differentiation, proliferation and apoptosis. Recent evidence also suggests their importance for cancerogenesis. By far the most important model systems in cancer research are mammalian organisms. Thus, we decided to compile comprehensive information on mammalian miRNAs, their origin and regulated target genes in an exhaustive, curated database called Argonaute (). Argonaute collects latest information from both literature and other databases. In contrast to current databases on miRNAs like miRBase::Sequences, NONCODE or RNAdb, Argonaute hosts additional information on the origin of an miRNA, i.e. in which host gene it is encoded, its expression in different tissues and its known or proposed function, its potential target genes including Gene Ontology annotation, as well as miRNA families and proteins known to be involved in miRNA processing. Additionally, target genes are linked to an information retrieval system that provides comprehensive information from sequence databases and a simultaneous search of MEDLINE with all synonyms of a given gene. The web interface allows the user to get information for a single or multiple miRNAs, either selected or uploaded through a text file. Argonaute currently has information on 839 miRNAs from human, mouse and rat.
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spelling pubmed-13474552006-01-25 Argonaute—a database for gene regulation by mammalian microRNAs Shahi, Priyanka Loukianiouk, Serguei Bohne-Lang, Andreas Kenzelmann, Marc Küffer, Stefan Maertens, Sabine Eils, Roland Gröne, Herrmann-Josef Gretz, Norbert Brors, Benedikt Nucleic Acids Res Article MicroRNAs (miRNAs) constitute a recently discovered class of small non-coding RNAs that regulate expression of target genes either by decreasing the stability of the target mRNA or by translational inhibition. They are involved in diverse processes, including cellular differentiation, proliferation and apoptosis. Recent evidence also suggests their importance for cancerogenesis. By far the most important model systems in cancer research are mammalian organisms. Thus, we decided to compile comprehensive information on mammalian miRNAs, their origin and regulated target genes in an exhaustive, curated database called Argonaute (). Argonaute collects latest information from both literature and other databases. In contrast to current databases on miRNAs like miRBase::Sequences, NONCODE or RNAdb, Argonaute hosts additional information on the origin of an miRNA, i.e. in which host gene it is encoded, its expression in different tissues and its known or proposed function, its potential target genes including Gene Ontology annotation, as well as miRNA families and proteins known to be involved in miRNA processing. Additionally, target genes are linked to an information retrieval system that provides comprehensive information from sequence databases and a simultaneous search of MEDLINE with all synonyms of a given gene. The web interface allows the user to get information for a single or multiple miRNAs, either selected or uploaded through a text file. Argonaute currently has information on 839 miRNAs from human, mouse and rat. Oxford University Press 2006-01-01 2005-12-28 /pmc/articles/PMC1347455/ /pubmed/16381827 http://dx.doi.org/10.1093/nar/gkj093 Text en © The Author 2006. Published by Oxford University Press. All rights reserved
spellingShingle Article
Shahi, Priyanka
Loukianiouk, Serguei
Bohne-Lang, Andreas
Kenzelmann, Marc
Küffer, Stefan
Maertens, Sabine
Eils, Roland
Gröne, Herrmann-Josef
Gretz, Norbert
Brors, Benedikt
Argonaute—a database for gene regulation by mammalian microRNAs
title Argonaute—a database for gene regulation by mammalian microRNAs
title_full Argonaute—a database for gene regulation by mammalian microRNAs
title_fullStr Argonaute—a database for gene regulation by mammalian microRNAs
title_full_unstemmed Argonaute—a database for gene regulation by mammalian microRNAs
title_short Argonaute—a database for gene regulation by mammalian microRNAs
title_sort argonaute—a database for gene regulation by mammalian micrornas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347455/
https://www.ncbi.nlm.nih.gov/pubmed/16381827
http://dx.doi.org/10.1093/nar/gkj093
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