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TRANSPATH(®): an information resource for storing and visualizing signaling pathways and their pathological aberrations

TRANSPATH(®) is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a number of orthogonal hierarchies reflecting the classification of t...

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Detalles Bibliográficos
Autores principales: Krull, Mathias, Pistor, Susanne, Voss, Nico, Kel, Alexander, Reuter, Ingmar, Kronenberg, Deborah, Michael, Holger, Schwarzer, Knut, Potapov, Anatolij, Choi, Claudia, Kel-Margoulis, Olga, Wingender, Edgar
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347469/
https://www.ncbi.nlm.nih.gov/pubmed/16381929
http://dx.doi.org/10.1093/nar/gkj107
Descripción
Sumario:TRANSPATH(®) is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a number of orthogonal hierarchies reflecting the classification of the molecules, their species-specific or generic features, and their post-translational modifications. Reactions are similarly hierarchically organized in a three-layer architecture, differentiating between reactions that are evidenced by individual publications, generalizations of these reactions to construct species-independent ‘reference pathways’ and the ‘semantic projections’ of these pathways. A number of search and browse options allow easy access to the database contents, which can be visualized with the tool PathwayBuilder™. The module PathoSign adds data about pathologically relevant mutations in signaling components, including their genotypes and phenotypes. TRANSPATH(®) and PathoSign can be used as encyclopaedia, in the educational process, for vizualization and modeling of signal transduction networks and for the analysis of gene expression data. TRANSPATH(®) Public 6.0 is freely accessible for users from non-profit organizations under .