Cargando…
TRANSPATH(®): an information resource for storing and visualizing signaling pathways and their pathological aberrations
TRANSPATH(®) is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a number of orthogonal hierarchies reflecting the classification of t...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2006
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347469/ https://www.ncbi.nlm.nih.gov/pubmed/16381929 http://dx.doi.org/10.1093/nar/gkj107 |
_version_ | 1782126625990639616 |
---|---|
author | Krull, Mathias Pistor, Susanne Voss, Nico Kel, Alexander Reuter, Ingmar Kronenberg, Deborah Michael, Holger Schwarzer, Knut Potapov, Anatolij Choi, Claudia Kel-Margoulis, Olga Wingender, Edgar |
author_facet | Krull, Mathias Pistor, Susanne Voss, Nico Kel, Alexander Reuter, Ingmar Kronenberg, Deborah Michael, Holger Schwarzer, Knut Potapov, Anatolij Choi, Claudia Kel-Margoulis, Olga Wingender, Edgar |
author_sort | Krull, Mathias |
collection | PubMed |
description | TRANSPATH(®) is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a number of orthogonal hierarchies reflecting the classification of the molecules, their species-specific or generic features, and their post-translational modifications. Reactions are similarly hierarchically organized in a three-layer architecture, differentiating between reactions that are evidenced by individual publications, generalizations of these reactions to construct species-independent ‘reference pathways’ and the ‘semantic projections’ of these pathways. A number of search and browse options allow easy access to the database contents, which can be visualized with the tool PathwayBuilder™. The module PathoSign adds data about pathologically relevant mutations in signaling components, including their genotypes and phenotypes. TRANSPATH(®) and PathoSign can be used as encyclopaedia, in the educational process, for vizualization and modeling of signal transduction networks and for the analysis of gene expression data. TRANSPATH(®) Public 6.0 is freely accessible for users from non-profit organizations under . |
format | Text |
id | pubmed-1347469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-13474692006-01-25 TRANSPATH(®): an information resource for storing and visualizing signaling pathways and their pathological aberrations Krull, Mathias Pistor, Susanne Voss, Nico Kel, Alexander Reuter, Ingmar Kronenberg, Deborah Michael, Holger Schwarzer, Knut Potapov, Anatolij Choi, Claudia Kel-Margoulis, Olga Wingender, Edgar Nucleic Acids Res Article TRANSPATH(®) is a database about signal transduction events. It provides information about signaling molecules, their reactions and the pathways these reactions constitute. The representation of signaling molecules is organized in a number of orthogonal hierarchies reflecting the classification of the molecules, their species-specific or generic features, and their post-translational modifications. Reactions are similarly hierarchically organized in a three-layer architecture, differentiating between reactions that are evidenced by individual publications, generalizations of these reactions to construct species-independent ‘reference pathways’ and the ‘semantic projections’ of these pathways. A number of search and browse options allow easy access to the database contents, which can be visualized with the tool PathwayBuilder™. The module PathoSign adds data about pathologically relevant mutations in signaling components, including their genotypes and phenotypes. TRANSPATH(®) and PathoSign can be used as encyclopaedia, in the educational process, for vizualization and modeling of signal transduction networks and for the analysis of gene expression data. TRANSPATH(®) Public 6.0 is freely accessible for users from non-profit organizations under . Oxford University Press 2006-01-01 2005-12-28 /pmc/articles/PMC1347469/ /pubmed/16381929 http://dx.doi.org/10.1093/nar/gkj107 Text en © The Author 2006. Published by Oxford University Press. All rights reserved |
spellingShingle | Article Krull, Mathias Pistor, Susanne Voss, Nico Kel, Alexander Reuter, Ingmar Kronenberg, Deborah Michael, Holger Schwarzer, Knut Potapov, Anatolij Choi, Claudia Kel-Margoulis, Olga Wingender, Edgar TRANSPATH(®): an information resource for storing and visualizing signaling pathways and their pathological aberrations |
title | TRANSPATH(®): an information resource for storing and visualizing signaling pathways and their pathological aberrations |
title_full | TRANSPATH(®): an information resource for storing and visualizing signaling pathways and their pathological aberrations |
title_fullStr | TRANSPATH(®): an information resource for storing and visualizing signaling pathways and their pathological aberrations |
title_full_unstemmed | TRANSPATH(®): an information resource for storing and visualizing signaling pathways and their pathological aberrations |
title_short | TRANSPATH(®): an information resource for storing and visualizing signaling pathways and their pathological aberrations |
title_sort | transpath(®): an information resource for storing and visualizing signaling pathways and their pathological aberrations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347469/ https://www.ncbi.nlm.nih.gov/pubmed/16381929 http://dx.doi.org/10.1093/nar/gkj107 |
work_keys_str_mv | AT krullmathias transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT pistorsusanne transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT vossnico transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT kelalexander transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT reuteringmar transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT kronenbergdeborah transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT michaelholger transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT schwarzerknut transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT potapovanatolij transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT choiclaudia transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT kelmargoulisolga transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations AT wingenderedgar transpathaninformationresourceforstoringandvisualizingsignalingpathwaysandtheirpathologicalaberrations |