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Reconstructing an Ancestral Mammalian Immune Supercomplex from a Marsupial Major Histocompatibility Complex

The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used theMonodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region o...

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Autores principales: Belov, Katherine, Deakin, Janine E, Papenfuss, Anthony T, Baker, Michelle L, Melman, Sandra D, Siddle, Hannah V, Gouin, Nicolas, Goode, David L, Sargeant, Tobias J, Robinson, Mark D, Wakefield, Matthew J, Mahony, Shaun, Cross, Joseph G. R, Benos, Panayiotis V, Samollow, Paul B, Speed, Terence P, Graves, Jennifer A. Marshall, Miller, Robert D
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351924/
https://www.ncbi.nlm.nih.gov/pubmed/16435885
http://dx.doi.org/10.1371/journal.pbio.0040046
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author Belov, Katherine
Deakin, Janine E
Papenfuss, Anthony T
Baker, Michelle L
Melman, Sandra D
Siddle, Hannah V
Gouin, Nicolas
Goode, David L
Sargeant, Tobias J
Robinson, Mark D
Wakefield, Matthew J
Mahony, Shaun
Cross, Joseph G. R
Benos, Panayiotis V
Samollow, Paul B
Speed, Terence P
Graves, Jennifer A. Marshall
Miller, Robert D
author_facet Belov, Katherine
Deakin, Janine E
Papenfuss, Anthony T
Baker, Michelle L
Melman, Sandra D
Siddle, Hannah V
Gouin, Nicolas
Goode, David L
Sargeant, Tobias J
Robinson, Mark D
Wakefield, Matthew J
Mahony, Shaun
Cross, Joseph G. R
Benos, Panayiotis V
Samollow, Paul B
Speed, Terence P
Graves, Jennifer A. Marshall
Miller, Robert D
author_sort Belov, Katherine
collection PubMed
description The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used theMonodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region of the mammalian genome and is critical to immunity and reproductive success. The marsupial MHC bridges the phylogenetic gap between the complex MHC of eutherian mammals and the minimal essential MHC of birds. Here we show that the opossum MHC is gene dense and complex, as in humans, but shares more organizational features with non-mammals. The Class I genes have amplified within the Class II region, resulting in a unique Class I/II region. We present a model of the organization of the MHC in ancestral mammals and its elaboration during mammalian evolution. The opossum genome, together with other extant genomes, reveals the existence of an ancestral “immune supercomplex” that contained genes of both types of natural killer receptors together with antigen processing genes and MHC genes.
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spelling pubmed-13519242006-01-31 Reconstructing an Ancestral Mammalian Immune Supercomplex from a Marsupial Major Histocompatibility Complex Belov, Katherine Deakin, Janine E Papenfuss, Anthony T Baker, Michelle L Melman, Sandra D Siddle, Hannah V Gouin, Nicolas Goode, David L Sargeant, Tobias J Robinson, Mark D Wakefield, Matthew J Mahony, Shaun Cross, Joseph G. R Benos, Panayiotis V Samollow, Paul B Speed, Terence P Graves, Jennifer A. Marshall Miller, Robert D PLoS Biol Research Article The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used theMonodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region of the mammalian genome and is critical to immunity and reproductive success. The marsupial MHC bridges the phylogenetic gap between the complex MHC of eutherian mammals and the minimal essential MHC of birds. Here we show that the opossum MHC is gene dense and complex, as in humans, but shares more organizational features with non-mammals. The Class I genes have amplified within the Class II region, resulting in a unique Class I/II region. We present a model of the organization of the MHC in ancestral mammals and its elaboration during mammalian evolution. The opossum genome, together with other extant genomes, reveals the existence of an ancestral “immune supercomplex” that contained genes of both types of natural killer receptors together with antigen processing genes and MHC genes. Public Library of Science 2006-03 2006-01-31 /pmc/articles/PMC1351924/ /pubmed/16435885 http://dx.doi.org/10.1371/journal.pbio.0040046 Text en Copyright: © 2006 Belov et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Belov, Katherine
Deakin, Janine E
Papenfuss, Anthony T
Baker, Michelle L
Melman, Sandra D
Siddle, Hannah V
Gouin, Nicolas
Goode, David L
Sargeant, Tobias J
Robinson, Mark D
Wakefield, Matthew J
Mahony, Shaun
Cross, Joseph G. R
Benos, Panayiotis V
Samollow, Paul B
Speed, Terence P
Graves, Jennifer A. Marshall
Miller, Robert D
Reconstructing an Ancestral Mammalian Immune Supercomplex from a Marsupial Major Histocompatibility Complex
title Reconstructing an Ancestral Mammalian Immune Supercomplex from a Marsupial Major Histocompatibility Complex
title_full Reconstructing an Ancestral Mammalian Immune Supercomplex from a Marsupial Major Histocompatibility Complex
title_fullStr Reconstructing an Ancestral Mammalian Immune Supercomplex from a Marsupial Major Histocompatibility Complex
title_full_unstemmed Reconstructing an Ancestral Mammalian Immune Supercomplex from a Marsupial Major Histocompatibility Complex
title_short Reconstructing an Ancestral Mammalian Immune Supercomplex from a Marsupial Major Histocompatibility Complex
title_sort reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351924/
https://www.ncbi.nlm.nih.gov/pubmed/16435885
http://dx.doi.org/10.1371/journal.pbio.0040046
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