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Long-term air pollution exposure and living close to busy roads are associated with COPD in women

BACKGROUND: Lung function and exacerbations of chronic obstructive pulmonary disease (COPD) have been associated with short-term exposure to air pollution. However, the effect of long-term exposure to particulate matter from industry and traffic on COPD as defined by lung function has not been evalu...

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Autores principales: Schikowski, Tamara, Sugiri, Dorothea, Ranft, Ulrich, Gehring, Ulrike, Heinrich, Joachim, Wichmann, H-Erich, Krämer, Ursula
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1352358/
https://www.ncbi.nlm.nih.gov/pubmed/16372913
http://dx.doi.org/10.1186/1465-9921-6-152
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author Schikowski, Tamara
Sugiri, Dorothea
Ranft, Ulrich
Gehring, Ulrike
Heinrich, Joachim
Wichmann, H-Erich
Krämer, Ursula
author_facet Schikowski, Tamara
Sugiri, Dorothea
Ranft, Ulrich
Gehring, Ulrike
Heinrich, Joachim
Wichmann, H-Erich
Krämer, Ursula
author_sort Schikowski, Tamara
collection PubMed
description BACKGROUND: Lung function and exacerbations of chronic obstructive pulmonary disease (COPD) have been associated with short-term exposure to air pollution. However, the effect of long-term exposure to particulate matter from industry and traffic on COPD as defined by lung function has not been evaluated so far. Our study was designed to investigate the influence of long-term exposure to air pollution on respiratory symptoms and pulmonary function in 55-year-old women. We especially focused on COPD as defined by GOLD criteria and additionally compared the effects of air pollution on respiratory symptoms by questionnaire data and by lung function measurements. METHODS: In consecutive cross sectional studies conducted between 1985–1994, we investigated 4757 women living in the Rhine-Ruhr Basin of Germany. NO(2 )and PM(10 )exposure was assessed by measurements done in an 8 km grid, and traffic exposure by distance from the residential address to the nearest major road using Geographic Information System data. Lung function was determined and COPD was defined by using the GOLD criteria. Chronic respiratory symptoms and possible confounders were defined by questionnaire data. Linear and logistic regressions, including random effects were used to account for confounding and clustering on city level. RESULTS: The prevalence of COPD (GOLD stages 1–4) was 4.5%. COPD and pulmonary function were strongest affected by PM(10 )and traffic related exposure. A 7 μg/m(3 )increase in five year means of PM(10 )(interquartile range) was associated with a 5.1% (95% CI 2.5%–7.7%) decrease in FEV(1), a 3.7% (95% CI 1.8%–5.5%) decrease in FVC and an odds ratio (OR) of 1.33 (95% CI 1.03–1.72) for COPD. Women living less than 100 m from a busy road also had a significantly decreased lung function and COPD was 1.79 times more likely (95% CI 1.06–3.02) than for those living farther away. Chronic symptoms as based on questionnaire information showed effects in the same direction, but less pronounced. CONCLUSION: Chronic exposure to PM(10), NO(2 )and living near a major road might increase the risk of developing COPD and can have a detrimental effect on lung function.
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spelling pubmed-13523582006-01-28 Long-term air pollution exposure and living close to busy roads are associated with COPD in women Schikowski, Tamara Sugiri, Dorothea Ranft, Ulrich Gehring, Ulrike Heinrich, Joachim Wichmann, H-Erich Krämer, Ursula Respir Res Research BACKGROUND: Lung function and exacerbations of chronic obstructive pulmonary disease (COPD) have been associated with short-term exposure to air pollution. However, the effect of long-term exposure to particulate matter from industry and traffic on COPD as defined by lung function has not been evaluated so far. Our study was designed to investigate the influence of long-term exposure to air pollution on respiratory symptoms and pulmonary function in 55-year-old women. We especially focused on COPD as defined by GOLD criteria and additionally compared the effects of air pollution on respiratory symptoms by questionnaire data and by lung function measurements. METHODS: In consecutive cross sectional studies conducted between 1985–1994, we investigated 4757 women living in the Rhine-Ruhr Basin of Germany. NO(2 )and PM(10 )exposure was assessed by measurements done in an 8 km grid, and traffic exposure by distance from the residential address to the nearest major road using Geographic Information System data. Lung function was determined and COPD was defined by using the GOLD criteria. Chronic respiratory symptoms and possible confounders were defined by questionnaire data. Linear and logistic regressions, including random effects were used to account for confounding and clustering on city level. RESULTS: The prevalence of COPD (GOLD stages 1–4) was 4.5%. COPD and pulmonary function were strongest affected by PM(10 )and traffic related exposure. A 7 μg/m(3 )increase in five year means of PM(10 )(interquartile range) was associated with a 5.1% (95% CI 2.5%–7.7%) decrease in FEV(1), a 3.7% (95% CI 1.8%–5.5%) decrease in FVC and an odds ratio (OR) of 1.33 (95% CI 1.03–1.72) for COPD. Women living less than 100 m from a busy road also had a significantly decreased lung function and COPD was 1.79 times more likely (95% CI 1.06–3.02) than for those living farther away. Chronic symptoms as based on questionnaire information showed effects in the same direction, but less pronounced. CONCLUSION: Chronic exposure to PM(10), NO(2 )and living near a major road might increase the risk of developing COPD and can have a detrimental effect on lung function. BioMed Central 2005 2005-12-22 /pmc/articles/PMC1352358/ /pubmed/16372913 http://dx.doi.org/10.1186/1465-9921-6-152 Text en Copyright © 2005 Schikowski et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Schikowski, Tamara
Sugiri, Dorothea
Ranft, Ulrich
Gehring, Ulrike
Heinrich, Joachim
Wichmann, H-Erich
Krämer, Ursula
Long-term air pollution exposure and living close to busy roads are associated with COPD in women
title Long-term air pollution exposure and living close to busy roads are associated with COPD in women
title_full Long-term air pollution exposure and living close to busy roads are associated with COPD in women
title_fullStr Long-term air pollution exposure and living close to busy roads are associated with COPD in women
title_full_unstemmed Long-term air pollution exposure and living close to busy roads are associated with COPD in women
title_short Long-term air pollution exposure and living close to busy roads are associated with COPD in women
title_sort long-term air pollution exposure and living close to busy roads are associated with copd in women
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1352358/
https://www.ncbi.nlm.nih.gov/pubmed/16372913
http://dx.doi.org/10.1186/1465-9921-6-152
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