BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status

BACKGROUND: BRAF is a member of RAF family of serine/threonine kinases and mediates cellular responses to growth signals through the RAS-RAF-MAP kinase pathway. Activating mutations in BRAF have recently been found in about 10% of colorectal cancers, with the vast majority being a V600E hotspot muta...

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Detalles Bibliográficos
Autores principales: Qi Li, Wei, Kawakami, Kazuyuki, Ruszkiewicz, Andrew, Bennett, Graeme, Moore, James, Iacopetta, Barry
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360090/
https://www.ncbi.nlm.nih.gov/pubmed/16403224
http://dx.doi.org/10.1186/1476-4598-5-2

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