Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels

BACKGROUND: SCF ubiquitin ligases target numerous proteins for ubiquitin dependent proteolysis, including p27 and cyclin E. SCF and other cullin-RING ligases (CRLs) are regulated by the ubiquitin-like protein Nedd8 that covalently modifies the cullin subunit. The removal of Nedd8 is catalyzed by the...

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Detalles Bibliográficos
Autores principales: Cope, Gregory A, Deshaies, Raymond J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360668/
https://www.ncbi.nlm.nih.gov/pubmed/16401342
http://dx.doi.org/10.1186/1471-2091-7-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360668/
https://www.ncbi.nlm.nih.gov/pubmed/16401342
http://dx.doi.org/10.1186/1471-2091-7-1

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