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Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels
BACKGROUND: SCF ubiquitin ligases target numerous proteins for ubiquitin dependent proteolysis, including p27 and cyclin E. SCF and other cullin-RING ligases (CRLs) are regulated by the ubiquitin-like protein Nedd8 that covalently modifies the cullin subunit. The removal of Nedd8 is catalyzed by the...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360668/ https://www.ncbi.nlm.nih.gov/pubmed/16401342 http://dx.doi.org/10.1186/1471-2091-7-1 |