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Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan

BACKGROUND: Apolipoprotein (Apo) A1 is a protective factor for cardiovascular events. This study aimed to perform complex segregation analyses of Apo A1 levels in families of adolescents systematically ascertained from the junior high school students in a rural community. Both siblings and parents o...

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Autores principales: Chien, Kuo-Liong, Chen, Wei J, Hsu, Hsiu-Ching, Su, Ta-Chen, Chen, Ming-Fong, Lee, Yuan-Teh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360683/
https://www.ncbi.nlm.nih.gov/pubmed/16423305
http://dx.doi.org/10.1186/1471-2156-7-4
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author Chien, Kuo-Liong
Chen, Wei J
Hsu, Hsiu-Ching
Su, Ta-Chen
Chen, Ming-Fong
Lee, Yuan-Teh
author_facet Chien, Kuo-Liong
Chen, Wei J
Hsu, Hsiu-Ching
Su, Ta-Chen
Chen, Ming-Fong
Lee, Yuan-Teh
author_sort Chien, Kuo-Liong
collection PubMed
description BACKGROUND: Apolipoprotein (Apo) A1 is a protective factor for cardiovascular events. This study aimed to perform complex segregation analyses of Apo A1 levels in families of adolescents systematically ascertained from the junior high school students in a rural community. Both siblings and parents of the adolescent probands were recruited for the study. Apo A1 concentrations were measured by turbidimetric immunoassay methods. After adjustment for gender, age, body mass index, smoking and drinking status, residual values of Apo A1 were subjected to subsequent analyses. RESULTS: Significant mother-father and parent-offspring correlations were found. Commingling analyses indicated that a four-component distribution model was needed to account for the Apo A1 variation. Segregation analysis using regressive models revealed that the best-fit model of Apo A1 was a model of environmental effect plus familial correlation (heritability = 23.9%), in which a significant mother-father correlation existed. Models containing major gene effect could be rejected. CONCLUSION: These results suggest that variations of Apo A1 levels in the normal range, especially during adolescence, are likely to be influenced by multiple factors without significant contribution from major genes.
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spelling pubmed-13606832006-02-04 Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan Chien, Kuo-Liong Chen, Wei J Hsu, Hsiu-Ching Su, Ta-Chen Chen, Ming-Fong Lee, Yuan-Teh BMC Genet Research Article BACKGROUND: Apolipoprotein (Apo) A1 is a protective factor for cardiovascular events. This study aimed to perform complex segregation analyses of Apo A1 levels in families of adolescents systematically ascertained from the junior high school students in a rural community. Both siblings and parents of the adolescent probands were recruited for the study. Apo A1 concentrations were measured by turbidimetric immunoassay methods. After adjustment for gender, age, body mass index, smoking and drinking status, residual values of Apo A1 were subjected to subsequent analyses. RESULTS: Significant mother-father and parent-offspring correlations were found. Commingling analyses indicated that a four-component distribution model was needed to account for the Apo A1 variation. Segregation analysis using regressive models revealed that the best-fit model of Apo A1 was a model of environmental effect plus familial correlation (heritability = 23.9%), in which a significant mother-father correlation existed. Models containing major gene effect could be rejected. CONCLUSION: These results suggest that variations of Apo A1 levels in the normal range, especially during adolescence, are likely to be influenced by multiple factors without significant contribution from major genes. BioMed Central 2006-01-20 /pmc/articles/PMC1360683/ /pubmed/16423305 http://dx.doi.org/10.1186/1471-2156-7-4 Text en Copyright © 2006 Chien et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chien, Kuo-Liong
Chen, Wei J
Hsu, Hsiu-Ching
Su, Ta-Chen
Chen, Ming-Fong
Lee, Yuan-Teh
Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan
title Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan
title_full Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan
title_fullStr Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan
title_full_unstemmed Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan
title_short Segregation analysis of apolipoprotein A1 levels in families of adolescents: A community-based study in Taiwan
title_sort segregation analysis of apolipoprotein a1 levels in families of adolescents: a community-based study in taiwan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360683/
https://www.ncbi.nlm.nih.gov/pubmed/16423305
http://dx.doi.org/10.1186/1471-2156-7-4
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