Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53

PARP-1 interacts with and poly(ADP-ribosyl)ates p53 and topoisomerase I, which both participate in DNA recombination. Previously, we showed that PARP-1 downregulates homology-directed double-strand break (DSB) repair. We also discovered that, despite the well-established role of p53 as a global supp...

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Detalles Bibliográficos
Autores principales: Baumann, Cindy, Boehden, Gisa S., Bürkle, Alexander, Wiesmüller, Lisa
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1363779/
https://www.ncbi.nlm.nih.gov/pubmed/16473854
http://dx.doi.org/10.1093/nar/gkj509

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