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Combination of methylated-DNA precipitation and methylation-sensitive restriction enzymes (COMPARE-MS) for the rapid, sensitive and quantitative detection of DNA methylation
Hypermethylation of CpG island (CGI) sequences is a nearly universal somatic genome alteration in cancer. Rapid and sensitive detection of DNA hypermethylation would aid in cancer diagnosis and risk stratification. We present a novel technique, called COMPARE-MS, that can rapidly and quantitatively...
Autores principales: | Yegnasubramanian, Srinivasan, Lin, Xiaohui, Haffner, Michael C., DeMarzo, Angelo M., Nelson, William G. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1363782/ https://www.ncbi.nlm.nih.gov/pubmed/16473842 http://dx.doi.org/10.1093/nar/gnj022 |
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