Cargando…

Why Do HIV-1 and HIV-2 Use Different Pathways to Develop AZT Resistance?

The human immunodeficiency virus type 1 (HIV-1) develops resistance to all available drugs, including the nucleoside analog reverse transcriptase inhibitors (NRTIs) such as AZT. ATP-mediated excision underlies the most common form of HIV-1 resistance to AZT. However, clinical data suggest that when...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boyer, Paul L, Sarafianos, Stefan G, Clark, Patrick K, Arnold, Eddy, Hughes, Stephen H
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364504/ https://www.ncbi.nlm.nih.gov/pubmed/16485036 http://dx.doi.org/10.1371/journal.ppat.0020010

Ejemplares similares

AZT 5’-Phosphonates: Achievements and Trends in the Treatment and Prevention of HIV Infection
por: Khandazhinskaya, А.L., et al.
Publicado: (2013)

Structures of Reverse Transcriptase Pre- and Post-Excision Complexes Shed New Light on HIV-1 AZT Resistance
por: Scott, Walter A.
Publicado: (2011)

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance
por: Das, Kalyan, et al.
Publicado: (2009)

AZT as a telomerase inhibitor
por: Gomez, Daniel E., et al.
Publicado: (2012)

Development of Triazoles and Triazolium Salts Based on AZT and Their Anti-Viral Activity against HIV-1
por: de Alencar, Daniel Machado, et al.
Publicado: (2021)

Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors
por: Singh, Kamalendra, et al.
Publicado: (2014)

Efficacy of Short-Course AZT Plus 3TC to Reduce Nevirapine Resistance in the Prevention of Mother-to-Child HIV Transmission: A Randomized Clinical Trial
por: McIntyre, James A., et al.
Publicado: (2009)

Zidovudine (AZT) Monotherapy Selects for the A360V Mutation in the Connection Domain of HIV-1 Reverse Transcriptase
por: Brehm, Jessica H., et al.
Publicado: (2012)

Hematological Changes in Women and Infants Exposed to an AZT-Containing Regimen for Prevention of Mother-to-Child-Transmission of HIV in Tanzania
por: Ziske, Judith, et al.
Publicado: (2013)

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors
por: Schneider, Anna, et al.
Publicado: (2016)

Neurotoxic effects of AZT on developing and adult neurogenesis
por: Demir, Meryem, et al.
Publicado: (2015)

Quercetin attenuates AZT-induced neuroinflammation in the CNS
por: Yang, Yi, et al.
Publicado: (2018)

Combining New Non-Nucleoside Reverse Transcriptase Inhibitors (RTIs) with AZT Results in Strong Synergism against Multi-RTI-Resistant HIV-1 Strains
por: Yu, Fei, et al.
Publicado: (2018)

AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase
por: Schneider, Anna, et al.
Publicado: (2015)

Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase
por: Singh, Kamal, et al.
Publicado: (2019)

Treatment of HIV-related primary central nervous system lymphoma with azt high dose, HAART, interleukin-2 and foscarnet in three patients
por: Marretta, L, et al.
Publicado: (2011)

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase
por: Singh, Kamalendra, et al.
Publicado: (2010)

Teratogenic and Embryocidal Effects of Zidovudine (AZT) in Sprague-Dawley Rats
por: Christmas, James T., et al.
Publicado: (1995)

Chemical and chemoenzymatic routes to bridged homoarabinofuranosylpyrimidines: Bicyclic AZT analogues
por: Kumar, Sandeep, et al.
Publicado: (2022)

AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP
por: Hartl, Maximilian J., et al.
Publicado: (2008)

Fully-spliced HIV-1 RNAs are reverse transcribed with similar efficiencies as the genomic RNA in virions and cells, but more efficiently in AZT-treated cells
por: Houzet, Laurent, et al.
Publicado: (2007)

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design
por: Bauman, Joseph D., et al.
Publicado: (2008)

Targeting the HIV-1 and HBV Capsids, an EnCore
por: McFadden, William M., et al.
Publicado: (2023)

Inhibition of ATL development in humanized mouse model by AZT/INF treatment
por: Tezuka, Kenta, et al.
Publicado: (2014)

IFN-α suppresses HTLV-1 expression via PKR in infected cells and renders them susceptible to AZT through p53 activation in AZT/IFN-α treatment
por: Kinpara, Shuichi, et al.
Publicado: (2014)

A novel mechanism of selectivity against AZT by the human mitochondrial DNA polymerase
por: Hanes, Jeremiah W., et al.
Publicado: (2007)

Why do marital partners of people living with HIV not test for HIV? A qualitative study in Lusaka, Zambia
por: Musheke, Maurice, et al.
Publicado: (2016)

Epistasis and entrenchment of drug resistance in HIV-1 subtype B
por: Biswas, Avik, et al.
Publicado: (2019)

Long-term AZT Exposure Alters the Metabolic Capacity of Cultured Human Lymphoblastoid Cells
por: Olivero, Ofelia A., et al.
Publicado: (2010)

1044. Aztreonam (AZT) vs. Cephalosporin (CEP) Therapy for the Treatment of Gram-Negative Bacteremia
por: Shah, Sunish, et al.
Publicado: (2018)

Structural Features Mediating Zinc Binding and Transfer in the AztABCD Zinc Transporter System
por: Meni, Anusha, et al.
Publicado: (2020)

Understanding why people participate in HIV surveillance
por: Zaba, Basia, et al.
Publicado: (2015)

Why is HIV not vector-borne?
por: Day, Troy, et al.
Publicado: (2008)

Visualization of HIV-1 RNA Transcription from Integrated HIV-1 DNA in Reactivated Latently Infected Cells
por: Ukah, Obiaara B., et al.
Publicado: (2018)

‘Fear overcome by love’: why I participated in HIV cure research
por: Hawley, Clark
Publicado: (2018)

Zidovudine (AZT) and Hepatic Lipid Accumulation: Implication of Inflammation, Oxidative and Endoplasmic Reticulum Stress Mediators
por: Banerjee, Atrayee, et al.
Publicado: (2013)

Revitalizing the AZT Through of the Selenium: An Approach in Human Triple Negative Breast Cancer Cell Line
por: Wagner, Mônica Silveira, et al.
Publicado: (2018)

Crystal structures of AztD provide mechanistic insights into direct zinc transfer between proteins
por: Neupane, Durga Prasad, et al.
Publicado: (2019)

Contributions of Conformational Flexibility to High-Affinity Zinc Binding in the Solute Binding Protein AztC
por: Serrano, Fred A., et al.
Publicado: (2022)

Amphipathic Small Molecule AZT Compound Displays Potent Inhibitory Effects in Cancer Cell Proliferation
por: Gunasekaran, Pethaiah, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hseetar0680mtp4dn57147e9eu