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Hypoxia-inducible factor-1α polymorphisms and TSC1/2 mutations are complementary in head and neck cancers
BACKGROUND: Polymorphisms or mutations in hypoxia inducible factor-1 alpha (HIF-1alpha) that increases its activity and stability under normoxia have recently been identified. Likewise, disruption of the TSC1/TSC2 complex through loss of TSC1 or TSC2 has been shown to result in abnormal accumulation...
Autores principales: | Hebert, Carla, Norris, Kathleen, Parashar, Pallavi, Ord, Robert A, Nikitakis, Nikolaos G, Sauk, John J |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1369006/ https://www.ncbi.nlm.nih.gov/pubmed/16412252 http://dx.doi.org/10.1186/1476-4598-5-3 |
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