Roughing up Smoothened: chemical modulators of Hedgehog signaling

Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway have also been identified. The finding that both antagonists and agonists target the protein Smoothened supports the emerging hypothesis...

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Detalles Bibliográficos
Autor principal: King, Randall W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137068/
https://www.ncbi.nlm.nih.gov/pubmed/12437769
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author King, Randall W
author_facet King, Randall W
author_sort King, Randall W
collection PubMed
description Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway have also been identified. The finding that both antagonists and agonists target the protein Smoothened supports the emerging hypothesis that Smoothened may be regulated by endogenous small molecules.
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spelling pubmed-1370682002-12-05 Roughing up Smoothened: chemical modulators of Hedgehog signaling King, Randall W J Biol Minireview Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway have also been identified. The finding that both antagonists and agonists target the protein Smoothened supports the emerging hypothesis that Smoothened may be regulated by endogenous small molecules. BioMed Central 2002 2002-11-06 /pmc/articles/PMC137068/ /pubmed/12437769 Text en Copyright © 2002 BioMed Central Ltd
spellingShingle Minireview
King, Randall W
Roughing up Smoothened: chemical modulators of Hedgehog signaling
title Roughing up Smoothened: chemical modulators of Hedgehog signaling
title_full Roughing up Smoothened: chemical modulators of Hedgehog signaling
title_fullStr Roughing up Smoothened: chemical modulators of Hedgehog signaling
title_full_unstemmed Roughing up Smoothened: chemical modulators of Hedgehog signaling
title_short Roughing up Smoothened: chemical modulators of Hedgehog signaling
title_sort roughing up smoothened: chemical modulators of hedgehog signaling
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137068/
https://www.ncbi.nlm.nih.gov/pubmed/12437769
work_keys_str_mv AT kingrandallw roughingupsmoothenedchemicalmodulatorsofhedgehogsignaling

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