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Do bronchodilators have an effect on bronchiolitis?
Over the past 12 years there have been 12 randomised control trials, involving 843 infants, evaluating the effect of salbutamol or albuterol on bronchiolitis. Of these, nine (75%) showed that bronchodilators had no effect. In three studies a small transient improvement in the acute clinical score wa...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137289/ https://www.ncbi.nlm.nih.gov/pubmed/11983033 http://dx.doi.org/10.1186/cc1466 |
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author | Schindler, Margrid |
author_facet | Schindler, Margrid |
author_sort | Schindler, Margrid |
collection | PubMed |
description | Over the past 12 years there have been 12 randomised control trials, involving 843 infants, evaluating the effect of salbutamol or albuterol on bronchiolitis. Of these, nine (75%) showed that bronchodilators had no effect. In three studies a small transient improvement in the acute clinical score was seen. Ipratropium bromide had no significant effect. There have been five recent randomised trials involving 225 infants, evaluating the effect of nebulised adrenaline (epinephrine) on bronchiolitis. All five (100%) have shown significant clinical improvement, with reductions in oxygen requirement, respiratory rate and wheeze after nebulised adrenaline. Two showed lower hospital admission rates and earlier discharge with adrenaline. A significant improvement in pulmonary resistance was observed after nebulised adrenaline but not after salbutamol or albuterol. Currently there is no compelling evidence that bronchodilators have a role in the routine management of infants with bronchiolitis. There is better evidence for the use of nebulised adrenaline. |
format | Text |
id | pubmed-137289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1372892003-02-27 Do bronchodilators have an effect on bronchiolitis? Schindler, Margrid Crit Care Commentary Over the past 12 years there have been 12 randomised control trials, involving 843 infants, evaluating the effect of salbutamol or albuterol on bronchiolitis. Of these, nine (75%) showed that bronchodilators had no effect. In three studies a small transient improvement in the acute clinical score was seen. Ipratropium bromide had no significant effect. There have been five recent randomised trials involving 225 infants, evaluating the effect of nebulised adrenaline (epinephrine) on bronchiolitis. All five (100%) have shown significant clinical improvement, with reductions in oxygen requirement, respiratory rate and wheeze after nebulised adrenaline. Two showed lower hospital admission rates and earlier discharge with adrenaline. A significant improvement in pulmonary resistance was observed after nebulised adrenaline but not after salbutamol or albuterol. Currently there is no compelling evidence that bronchodilators have a role in the routine management of infants with bronchiolitis. There is better evidence for the use of nebulised adrenaline. BioMed Central 2002 2002-03-11 /pmc/articles/PMC137289/ /pubmed/11983033 http://dx.doi.org/10.1186/cc1466 Text en Copyright © 2002 BioMed Central Ltd |
spellingShingle | Commentary Schindler, Margrid Do bronchodilators have an effect on bronchiolitis? |
title | Do bronchodilators have an effect on bronchiolitis? |
title_full | Do bronchodilators have an effect on bronchiolitis? |
title_fullStr | Do bronchodilators have an effect on bronchiolitis? |
title_full_unstemmed | Do bronchodilators have an effect on bronchiolitis? |
title_short | Do bronchodilators have an effect on bronchiolitis? |
title_sort | do bronchodilators have an effect on bronchiolitis? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137289/ https://www.ncbi.nlm.nih.gov/pubmed/11983033 http://dx.doi.org/10.1186/cc1466 |
work_keys_str_mv | AT schindlermargrid dobronchodilatorshaveaneffectonbronchiolitis |