Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer

BACKGROUND: Women with homozygous polymorphic alleles of catechol-O-methyltransferase (COMT-LL) metabolize 2-hydroxylated estradiol, a suspected anticarcinogenic metabolite of estrogen, at a four-fold lower rate than women with no polymorphic alleles (COMT-HH) or heterozygous women (COMT-HL). We hyp...

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Bibliographic Details
Main Authors: Bradbury, Brian D, Wilk, Jemma B, Aschengrau, Ann, Lash, Timothy L
Format: Text
Language:English
Published: BioMed Central 2006
Subjects:
Research
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1373621/
https://www.ncbi.nlm.nih.gov/pubmed/16417624
http://dx.doi.org/10.1186/1477-3163-5-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1373621/
https://www.ncbi.nlm.nih.gov/pubmed/16417624
http://dx.doi.org/10.1186/1477-3163-5-3

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