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Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer
BACKGROUND: Women with homozygous polymorphic alleles of catechol-O-methyltransferase (COMT-LL) metabolize 2-hydroxylated estradiol, a suspected anticarcinogenic metabolite of estrogen, at a four-fold lower rate than women with no polymorphic alleles (COMT-HH) or heterozygous women (COMT-HL). We hyp...
Main Authors: | , , , |
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Format: | Text |
Language: | English |
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BioMed Central
2006
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1373621/ https://www.ncbi.nlm.nih.gov/pubmed/16417624 http://dx.doi.org/10.1186/1477-3163-5-3 |