Structural and functional properties of genes involved in human cancer

BACKGROUND: One of the main goals of cancer genetics is to identify the causative elements at the molecular level leading to cancer. RESULTS: We have conducted an analysis of a set of genes known to be involved in cancer in order to unveil their unique features that can assist towards the identifica...

Descripción completa

Detalles Bibliográficos
Autores principales: Furney, Simon J, Higgins, Desmond G, Ouzounis, Christos A, López-Bigas, Núria
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1373651/
https://www.ncbi.nlm.nih.gov/pubmed/16405732
http://dx.doi.org/10.1186/1471-2164-7-3
_version_ 1782126808370511872
author Furney, Simon J
Higgins, Desmond G
Ouzounis, Christos A
López-Bigas, Núria
author_facet Furney, Simon J
Higgins, Desmond G
Ouzounis, Christos A
López-Bigas, Núria
author_sort Furney, Simon J
collection PubMed
description BACKGROUND: One of the main goals of cancer genetics is to identify the causative elements at the molecular level leading to cancer. RESULTS: We have conducted an analysis of a set of genes known to be involved in cancer in order to unveil their unique features that can assist towards the identification of new candidate cancer genes. CONCLUSION: We have detected key patterns in this group of genes in terms of the molecular function or the biological process in which they are involved as well as sequence properties. Based on these features we have developed an accurate Bayesian classification model with which human genes have been scored for their likelihood of involvement in cancer.
format Text
id pubmed-1373651
institution National Center for Biotechnology Information
language English
publishDate 2006
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-13736512006-02-18 Structural and functional properties of genes involved in human cancer Furney, Simon J Higgins, Desmond G Ouzounis, Christos A López-Bigas, Núria BMC Genomics Research Article BACKGROUND: One of the main goals of cancer genetics is to identify the causative elements at the molecular level leading to cancer. RESULTS: We have conducted an analysis of a set of genes known to be involved in cancer in order to unveil their unique features that can assist towards the identification of new candidate cancer genes. CONCLUSION: We have detected key patterns in this group of genes in terms of the molecular function or the biological process in which they are involved as well as sequence properties. Based on these features we have developed an accurate Bayesian classification model with which human genes have been scored for their likelihood of involvement in cancer. BioMed Central 2006-01-11 /pmc/articles/PMC1373651/ /pubmed/16405732 http://dx.doi.org/10.1186/1471-2164-7-3 Text en Copyright © 2006 Furney et al; licensee BioMed Central Ltd.
spellingShingle Research Article
Furney, Simon J
Higgins, Desmond G
Ouzounis, Christos A
López-Bigas, Núria
Structural and functional properties of genes involved in human cancer
title Structural and functional properties of genes involved in human cancer
title_full Structural and functional properties of genes involved in human cancer
title_fullStr Structural and functional properties of genes involved in human cancer
title_full_unstemmed Structural and functional properties of genes involved in human cancer
title_short Structural and functional properties of genes involved in human cancer
title_sort structural and functional properties of genes involved in human cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1373651/
https://www.ncbi.nlm.nih.gov/pubmed/16405732
http://dx.doi.org/10.1186/1471-2164-7-3
work_keys_str_mv AT furneysimonj structuralandfunctionalpropertiesofgenesinvolvedinhumancancer
AT higginsdesmondg structuralandfunctionalpropertiesofgenesinvolvedinhumancancer
AT ouzounischristosa structuralandfunctionalpropertiesofgenesinvolvedinhumancancer
AT lopezbigasnuria structuralandfunctionalpropertiesofgenesinvolvedinhumancancer

Ejemplares similares