Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models

BACKGROUND: Transgenic mice have proven to be a powerful system to study normal and pathological gene functions. Here we describe an attempt to generate a transgenic mouse model for choroideremia (CHM), a slow-onset X-linked retinal degeneration caused by mutations in the Rab Escort Protein-1 (REP1)...

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Detalles Bibliográficos
Autores principales: Ramalho, José S, Anders, Ross, Jaissle, Gesine B, Seeliger, Mathias W, Huxley, Clare, Seabra, Miguel C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137576/
https://www.ncbi.nlm.nih.gov/pubmed/12401133
http://dx.doi.org/10.1186/1471-2121-3-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137576/
https://www.ncbi.nlm.nih.gov/pubmed/12401133
http://dx.doi.org/10.1186/1471-2121-3-26

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