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Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models
BACKGROUND: Transgenic mice have proven to be a powerful system to study normal and pathological gene functions. Here we describe an attempt to generate a transgenic mouse model for choroideremia (CHM), a slow-onset X-linked retinal degeneration caused by mutations in the Rab Escort Protein-1 (REP1)...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2002
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137576/ https://www.ncbi.nlm.nih.gov/pubmed/12401133 http://dx.doi.org/10.1186/1471-2121-3-26 |