Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function

Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in...

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Detalles Bibliográficos
Autores principales: Marshman, Emma, Streuli, Charles H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137936/
https://www.ncbi.nlm.nih.gov/pubmed/12473169
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author Marshman, Emma
Streuli, Charles H
author_facet Marshman, Emma
Streuli, Charles H
author_sort Marshman, Emma
collection PubMed
description Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in the mammary gland and describes how modulation of their actions occurs by association with hormones, other growth factors and the extracellular matrix. The review will also highlight the involvement of the IGF axis in breast cancer.
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spelling pubmed-1379362003-01-20 Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function Marshman, Emma Streuli, Charles H Breast Cancer Res Review Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in the mammary gland and describes how modulation of their actions occurs by association with hormones, other growth factors and the extracellular matrix. The review will also highlight the involvement of the IGF axis in breast cancer. BioMed Central 2002 2002-08-29 /pmc/articles/PMC137936/ /pubmed/12473169 Text en Copyright © 2002 BioMed Central Ltd
spellingShingle Review
Marshman, Emma
Streuli, Charles H
Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
title Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
title_full Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
title_fullStr Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
title_full_unstemmed Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
title_short Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
title_sort insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137936/
https://www.ncbi.nlm.nih.gov/pubmed/12473169
work_keys_str_mv AT marshmanemma insulinlikegrowthfactorsandinsulinlikegrowthfactorbindingproteinsinmammaryglandfunction
AT streulicharlesh insulinlikegrowthfactorsandinsulinlikegrowthfactorbindingproteinsinmammaryglandfunction

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