Prolactin signaling and Stat5: going their own separate ways?

Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by studying PrlR(-/-) and Stat5ab(-/-) mouse mammary epithelial transplants during pregnancy. At first gl...

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Detalles Bibliográficos
Autores principales: Brisken, Cathrin, Ayyanan, Ayyakkannu, Doppler, Wolfgang
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137942/
https://www.ncbi.nlm.nih.gov/pubmed/12473164
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author Brisken, Cathrin
Ayyanan, Ayyakkannu
Doppler, Wolfgang
author_facet Brisken, Cathrin
Ayyanan, Ayyakkannu
Doppler, Wolfgang
author_sort Brisken, Cathrin
collection PubMed
description Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by studying PrlR(-/-) and Stat5ab(-/-) mouse mammary epithelial transplants during pregnancy. At first glance, the two mutant epithelia appear to have similar defects in the differentiation of the alveolar epithelium. However, a closer examination by Miyoshi et al. revealed defects in the epithelial architecture of the smallest ducts of Stat5ab(-/-) transplants not apparent in the PrlR(-/-) transplants, suggesting that Stat5 is more than a simple mediator of PrlR action.
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spelling pubmed-1379422003-01-20 Prolactin signaling and Stat5: going their own separate ways? Brisken, Cathrin Ayyanan, Ayyakkannu Doppler, Wolfgang Breast Cancer Res Commentary Miyoshi et al. compared the role of the prolactin receptor (PrlR) and its downstream mediator, the signal transducer and activator of transcription 5 (Stat5), in mammary epithelial cells in vivo by studying PrlR(-/-) and Stat5ab(-/-) mouse mammary epithelial transplants during pregnancy. At first glance, the two mutant epithelia appear to have similar defects in the differentiation of the alveolar epithelium. However, a closer examination by Miyoshi et al. revealed defects in the epithelial architecture of the smallest ducts of Stat5ab(-/-) transplants not apparent in the PrlR(-/-) transplants, suggesting that Stat5 is more than a simple mediator of PrlR action. BioMed Central 2002 2002-10-03 /pmc/articles/PMC137942/ /pubmed/12473164 Text en Copyright © 2002 BioMed Central Ltd
spellingShingle Commentary
Brisken, Cathrin
Ayyanan, Ayyakkannu
Doppler, Wolfgang
Prolactin signaling and Stat5: going their own separate ways?
title Prolactin signaling and Stat5: going their own separate ways?
title_full Prolactin signaling and Stat5: going their own separate ways?
title_fullStr Prolactin signaling and Stat5: going their own separate ways?
title_full_unstemmed Prolactin signaling and Stat5: going their own separate ways?
title_short Prolactin signaling and Stat5: going their own separate ways?
title_sort prolactin signaling and stat5: going their own separate ways?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137942/
https://www.ncbi.nlm.nih.gov/pubmed/12473164
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