Glutamine-Expanded Ataxin-7 Alters TFTC/STAGA Recruitment and Chromatin Structure Leading to Photoreceptor Dysfunction

Spinocerebellar ataxia type 7 (SCA7) is one of several inherited neurodegenerative disorders caused by a polyglutamine (polyQ) expansion, but it is the only one in which the retina is affected. Increasing evidence suggests that transcriptional alterations contribute to polyQ pathogenesis, although t...

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Detalles Bibliográficos
Autores principales: Helmlinger, Dominique, Hardy, Sara, Abou-Sleymane, Gretta, Eberlin, Adrien, Bowman, Aaron B, Gansmüller, Anne, Picaud, Serge, Zoghbi, Huda Y, Trottier, Yvon, Tora, Làszlò, Devys, Didier
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1382020/
https://www.ncbi.nlm.nih.gov/pubmed/16494529
http://dx.doi.org/10.1371/journal.pbio.0040067

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