HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1

BACKGROUND: Heparin/heparan sulfate (HS) proteoglycans are found in the extracellular matrix (ECM) and on the cell surface. A considerable body of evidence has established that heparin and heparan sulfate proteoglycans (HSPGs) interact with numerous protein ligands including fibroblast growth factor...

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Detalles Bibliográficos
Autores principales: Uchimura, Kenji, Morimoto-Tomita, Megumi, Bistrup, Annette, Li, Jessica, Lyon, Malcolm, Gallagher, John, Werb, Zena, Rosen, Steven D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386684/
https://www.ncbi.nlm.nih.gov/pubmed/16417632
http://dx.doi.org/10.1186/1471-2091-7-2

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