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Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics?
Since its identification, much information has been obtained about prostate-specific antigen (PSA, or human glandular kallikrein 3 [hK3]), a kallikrein-like serine protease that is the most valuable tumour marker for the screening, diagnosis and management of human prostate carcinoma. Recently, it h...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2001
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138688/ https://www.ncbi.nlm.nih.gov/pubmed/11434875 http://dx.doi.org/10.1186/bcr302 |
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author | Mannello, Ferdinando Gazzanelli, Giancarlo |
author_facet | Mannello, Ferdinando Gazzanelli, Giancarlo |
author_sort | Mannello, Ferdinando |
collection | PubMed |
description | Since its identification, much information has been obtained about prostate-specific antigen (PSA, or human glandular kallikrein 3 [hK3]), a kallikrein-like serine protease that is the most valuable tumour marker for the screening, diagnosis and management of human prostate carcinoma. Recently, it has become widely accepted that PSA is also present in many nonprostatic sources, casting doubts about the specificity of its tissue expression. Here we summarize the findings on the biomolecular expression of PSA in breast secretions, cells and tissues of healthy and diseased females. Although several studies have strongly suggested that the molecular forms of PSA seem to represent a potential tool for the risk assessment of breast cancer, recent reports have yielded conflicting results. Although several studies have suggested new biological function(s) for PSA in breast physiopathology, more studies are needed to enlist PSA unequivocally as an additional weapon in the anticancer armoury in breast cancer diagnostics. |
format | Text |
id | pubmed-138688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1386882003-02-27 Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics? Mannello, Ferdinando Gazzanelli, Giancarlo Breast Cancer Res Review Since its identification, much information has been obtained about prostate-specific antigen (PSA, or human glandular kallikrein 3 [hK3]), a kallikrein-like serine protease that is the most valuable tumour marker for the screening, diagnosis and management of human prostate carcinoma. Recently, it has become widely accepted that PSA is also present in many nonprostatic sources, casting doubts about the specificity of its tissue expression. Here we summarize the findings on the biomolecular expression of PSA in breast secretions, cells and tissues of healthy and diseased females. Although several studies have strongly suggested that the molecular forms of PSA seem to represent a potential tool for the risk assessment of breast cancer, recent reports have yielded conflicting results. Although several studies have suggested new biological function(s) for PSA in breast physiopathology, more studies are needed to enlist PSA unequivocally as an additional weapon in the anticancer armoury in breast cancer diagnostics. BioMed Central 2001 2001-05-10 /pmc/articles/PMC138688/ /pubmed/11434875 http://dx.doi.org/10.1186/bcr302 Text en Copyright © 2001 BioMed Central Ltd |
spellingShingle | Review Mannello, Ferdinando Gazzanelli, Giancarlo Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics? |
title | Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics? |
title_full | Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics? |
title_fullStr | Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics? |
title_full_unstemmed | Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics? |
title_short | Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics? |
title_sort | prostate-specific antigen (psa/hk3): a further player in the field of breast cancer diagnostics? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138688/ https://www.ncbi.nlm.nih.gov/pubmed/11434875 http://dx.doi.org/10.1186/bcr302 |
work_keys_str_mv | AT mannelloferdinando prostatespecificantigenpsahk3afurtherplayerinthefieldofbreastcancerdiagnostics AT gazzanelligiancarlo prostatespecificantigenpsahk3afurtherplayerinthefieldofbreastcancerdiagnostics |