Hypoxia and oxidative stress in breast cancer: Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer

Reactive oxygen species (ROS) damage DNA, but the role of ROS in breast carcinoma may not be limited to the mutagenic activity that drives carcinoma initiation and progression. Carcinoma cells in vitro and in vivo are frequently under persistent oxidative stress. In the present review, we outline po...

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Detalles Bibliográficos
Autores principales: Brown, Nicholas S, Bicknell, Roy
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138696/
https://www.ncbi.nlm.nih.gov/pubmed/11597322
http://dx.doi.org/10.1186/bcr315
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author Brown, Nicholas S
Bicknell, Roy
author_facet Brown, Nicholas S
Bicknell, Roy
author_sort Brown, Nicholas S
collection PubMed
description Reactive oxygen species (ROS) damage DNA, but the role of ROS in breast carcinoma may not be limited to the mutagenic activity that drives carcinoma initiation and progression. Carcinoma cells in vitro and in vivo are frequently under persistent oxidative stress. In the present review, we outline potential causes of oxygen radical generation within carcinoma cells and explore the possible impact of oxidative stress on the clinical outcome of breast carcinoma.
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spelling pubmed-1386962003-02-27 Hypoxia and oxidative stress in breast cancer: Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer Brown, Nicholas S Bicknell, Roy Breast Cancer Res Review Reactive oxygen species (ROS) damage DNA, but the role of ROS in breast carcinoma may not be limited to the mutagenic activity that drives carcinoma initiation and progression. Carcinoma cells in vitro and in vivo are frequently under persistent oxidative stress. In the present review, we outline potential causes of oxygen radical generation within carcinoma cells and explore the possible impact of oxidative stress on the clinical outcome of breast carcinoma. BioMed Central 2001 2001-07-23 /pmc/articles/PMC138696/ /pubmed/11597322 http://dx.doi.org/10.1186/bcr315 Text en Copyright © 2001 BioMed Central Ltd
spellingShingle Review
Brown, Nicholas S
Bicknell, Roy
Hypoxia and oxidative stress in breast cancer: Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer
title Hypoxia and oxidative stress in breast cancer: Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer
title_full Hypoxia and oxidative stress in breast cancer: Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer
title_fullStr Hypoxia and oxidative stress in breast cancer: Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer
title_full_unstemmed Hypoxia and oxidative stress in breast cancer: Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer
title_short Hypoxia and oxidative stress in breast cancer: Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer
title_sort hypoxia and oxidative stress in breast cancer: oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138696/
https://www.ncbi.nlm.nih.gov/pubmed/11597322
http://dx.doi.org/10.1186/bcr315
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AT bicknellroy hypoxiaandoxidativestressinbreastcanceroxidativestressitseffectsonthegrowthmetastaticpotentialandresponsetotherapyofbreastcancer

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