Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?

Brca1 is involved in multiple biological pathways including DNA damage repair, transcriptional regulation, and cell-cycle progression. A complex pattern of interactions of Brca1 with Trp53 has also emerged. Xu and coworkers found that haploid loss of Trp53 significantly reduces the embryonic lethali...

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Detalles Bibliográficos
Autores principales: McAllister, Kimberly A, Wiseman, Roger W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138719/
https://www.ncbi.nlm.nih.gov/pubmed/11879563
http://dx.doi.org/10.1186/bcr422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138719/
https://www.ncbi.nlm.nih.gov/pubmed/11879563
http://dx.doi.org/10.1186/bcr422

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