A new model for ductal carcinoma in situ suggests strategies for treatment

Human ductal carcinoma in situ (DCIS) of the breast is now diagnosed quite frequently, due largely to the introduction of mammographic screening. It has been shown in a cell culture system that activation of c-erbB-2, but not the epidermal growth factor receptor, results in a DCIS-like phenotype. Si...

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Detalles Bibliográficos
Autor principal: Gullick, William John
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138739/
https://www.ncbi.nlm.nih.gov/pubmed/12223119
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author Gullick, William John
author_facet Gullick, William John
author_sort Gullick, William John
collection PubMed
description Human ductal carcinoma in situ (DCIS) of the breast is now diagnosed quite frequently, due largely to the introduction of mammographic screening. It has been shown in a cell culture system that activation of c-erbB-2, but not the epidermal growth factor receptor, results in a DCIS-like phenotype. Since overexpression of c-erbB-2 occurs in 60% of DCIS, this suggests that it could be a target for treatment in this disease.
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spelling pubmed-1387392003-02-27 A new model for ductal carcinoma in situ suggests strategies for treatment Gullick, William John Breast Cancer Res Commentary Human ductal carcinoma in situ (DCIS) of the breast is now diagnosed quite frequently, due largely to the introduction of mammographic screening. It has been shown in a cell culture system that activation of c-erbB-2, but not the epidermal growth factor receptor, results in a DCIS-like phenotype. Since overexpression of c-erbB-2 occurs in 60% of DCIS, this suggests that it could be a target for treatment in this disease. BioMed Central 2002 2002-07-19 /pmc/articles/PMC138739/ /pubmed/12223119 Text en Copyright © 2002 2002 BioMed Central Ltd
spellingShingle Commentary
Gullick, William John
A new model for ductal carcinoma in situ suggests strategies for treatment
title A new model for ductal carcinoma in situ suggests strategies for treatment
title_full A new model for ductal carcinoma in situ suggests strategies for treatment
title_fullStr A new model for ductal carcinoma in situ suggests strategies for treatment
title_full_unstemmed A new model for ductal carcinoma in situ suggests strategies for treatment
title_short A new model for ductal carcinoma in situ suggests strategies for treatment
title_sort new model for ductal carcinoma in situ suggests strategies for treatment
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138739/
https://www.ncbi.nlm.nih.gov/pubmed/12223119
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