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Post-radiation dedifferentiation of meningioma into osteosarcoma.
BACKGROUND: A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION: In 1987 a caucasian...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138810/ https://www.ncbi.nlm.nih.gov/pubmed/12464160 http://dx.doi.org/10.1186/1471-2407-2-34 |
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author | Osipov, Vladimir Ho, Khang-Che Krouwer, Hendrikus G Meyer, Glenn Shidham, Vinod B |
author_facet | Osipov, Vladimir Ho, Khang-Che Krouwer, Hendrikus G Meyer, Glenn Shidham, Vinod B |
author_sort | Osipov, Vladimir |
collection | PubMed |
description | BACKGROUND: A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION: In 1987 a caucasian man, then 38 years old, presented with a pituitary macroadenoma. He underwent a subtotal resection of the tumor and did well until 1990 when a recurrent tumor was diagnosed. This was treated with subtotal resection of the tumor, followed by radiation therapy for six weeks to a total of 54 Gy. He was considered "disease-free" for nearly ten years. However, most recently in July 2000, he presented with a visual field deficit due to a second recurrence of his pituitary macroadenoma, now with suprasellar extension. At this time, as an incidental finding, a mass attached to the dura was noted in the left parietal hemisphere. This dura–based mass had grown rapidly by January 2001 and was excised. It showed histological, immunohistochemical, and electron microscopic features of malignant meningioma and osteosarcoma with a sharp demarcation between the two components. CONCLUSIONS: We report a rare case of a radiation induced dedifferentiation of meningioma into osteosarcoma, which has not been reported previously. |
format | Text |
id | pubmed-138810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1388102002-12-19 Post-radiation dedifferentiation of meningioma into osteosarcoma. Osipov, Vladimir Ho, Khang-Che Krouwer, Hendrikus G Meyer, Glenn Shidham, Vinod B BMC Cancer Case Report BACKGROUND: A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosarcoma has not been reported previously. CASE PRESENTATION: In 1987 a caucasian man, then 38 years old, presented with a pituitary macroadenoma. He underwent a subtotal resection of the tumor and did well until 1990 when a recurrent tumor was diagnosed. This was treated with subtotal resection of the tumor, followed by radiation therapy for six weeks to a total of 54 Gy. He was considered "disease-free" for nearly ten years. However, most recently in July 2000, he presented with a visual field deficit due to a second recurrence of his pituitary macroadenoma, now with suprasellar extension. At this time, as an incidental finding, a mass attached to the dura was noted in the left parietal hemisphere. This dura–based mass had grown rapidly by January 2001 and was excised. It showed histological, immunohistochemical, and electron microscopic features of malignant meningioma and osteosarcoma with a sharp demarcation between the two components. CONCLUSIONS: We report a rare case of a radiation induced dedifferentiation of meningioma into osteosarcoma, which has not been reported previously. BioMed Central 2002-12-03 /pmc/articles/PMC138810/ /pubmed/12464160 http://dx.doi.org/10.1186/1471-2407-2-34 Text en Copyright © 2002 Osipov et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Case Report Osipov, Vladimir Ho, Khang-Che Krouwer, Hendrikus G Meyer, Glenn Shidham, Vinod B Post-radiation dedifferentiation of meningioma into osteosarcoma. |
title | Post-radiation dedifferentiation of meningioma into osteosarcoma. |
title_full | Post-radiation dedifferentiation of meningioma into osteosarcoma. |
title_fullStr | Post-radiation dedifferentiation of meningioma into osteosarcoma. |
title_full_unstemmed | Post-radiation dedifferentiation of meningioma into osteosarcoma. |
title_short | Post-radiation dedifferentiation of meningioma into osteosarcoma. |
title_sort | post-radiation dedifferentiation of meningioma into osteosarcoma. |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138810/ https://www.ncbi.nlm.nih.gov/pubmed/12464160 http://dx.doi.org/10.1186/1471-2407-2-34 |
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