The sequence of human chromosome 21 and implications for research into Down syndrome

The recent completion of the DNA sequence of human chromosome 21 has provided the first look at the 225 genes that are candidates for involvement in Down syndrome (trisomy 21). A broad functional classification of these genes, their expression data and evolutionary conservation, and comparison with...

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Detalles Bibliográficos
Autores principales: Gardiner, Katheleen, Davisson, Muriel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138845/
https://www.ncbi.nlm.nih.gov/pubmed/11178230
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author Gardiner, Katheleen
Davisson, Muriel
author_facet Gardiner, Katheleen
Davisson, Muriel
author_sort Gardiner, Katheleen
collection PubMed
description The recent completion of the DNA sequence of human chromosome 21 has provided the first look at the 225 genes that are candidates for involvement in Down syndrome (trisomy 21). A broad functional classification of these genes, their expression data and evolutionary conservation, and comparison with the gene content of the major mouse models of Down syndrome, suggest how the chromosome sequence may help in understanding the complex Down syndrome phenotype.
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spelling pubmed-1388452003-03-03 The sequence of human chromosome 21 and implications for research into Down syndrome Gardiner, Katheleen Davisson, Muriel Genome Biol Review The recent completion of the DNA sequence of human chromosome 21 has provided the first look at the 225 genes that are candidates for involvement in Down syndrome (trisomy 21). A broad functional classification of these genes, their expression data and evolutionary conservation, and comparison with the gene content of the major mouse models of Down syndrome, suggest how the chromosome sequence may help in understanding the complex Down syndrome phenotype. BioMed Central 2000 2000-08-04 /pmc/articles/PMC138845/ /pubmed/11178230 Text en Copyright © 2000 GenomeBiology.com
spellingShingle Review
Gardiner, Katheleen
Davisson, Muriel
The sequence of human chromosome 21 and implications for research into Down syndrome
title The sequence of human chromosome 21 and implications for research into Down syndrome
title_full The sequence of human chromosome 21 and implications for research into Down syndrome
title_fullStr The sequence of human chromosome 21 and implications for research into Down syndrome
title_full_unstemmed The sequence of human chromosome 21 and implications for research into Down syndrome
title_short The sequence of human chromosome 21 and implications for research into Down syndrome
title_sort sequence of human chromosome 21 and implications for research into down syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138845/
https://www.ncbi.nlm.nih.gov/pubmed/11178230
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