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Secret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutation

A new mechanism for regulation in the immune system has been identified: a cytidine deaminase is critical for both class switch recombination and somatic hypermutation, revealing an unanticipated link between these two processes.

Detalles Bibliográficos
Autor principal: Maizels, Nancy
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138873/
https://www.ncbi.nlm.nih.gov/pubmed/11178252
Descripción
Sumario:A new mechanism for regulation in the immune system has been identified: a cytidine deaminase is critical for both class switch recombination and somatic hypermutation, revealing an unanticipated link between these two processes.