Can sequence determine function?

The functional annotation of proteins identified in genome sequencing projects is based on similarities to homologs in the databases. As a result of the possible strategies for divergent evolution, homologous enzymes frequently do not catalyze the same reaction, and we conclude that assignment of fu...

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Detalles Bibliográficos
Autores principales: Gerlt, John A, Babbitt, Patricia C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138884/
https://www.ncbi.nlm.nih.gov/pubmed/11178260
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author Gerlt, John A
Babbitt, Patricia C
author_facet Gerlt, John A
Babbitt, Patricia C
author_sort Gerlt, John A
collection PubMed
description The functional annotation of proteins identified in genome sequencing projects is based on similarities to homologs in the databases. As a result of the possible strategies for divergent evolution, homologous enzymes frequently do not catalyze the same reaction, and we conclude that assignment of function from sequence information alone should be viewed with some skepticism.
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spelling pubmed-1388842003-03-03 Can sequence determine function? Gerlt, John A Babbitt, Patricia C Genome Biol Review The functional annotation of proteins identified in genome sequencing projects is based on similarities to homologs in the databases. As a result of the possible strategies for divergent evolution, homologous enzymes frequently do not catalyze the same reaction, and we conclude that assignment of function from sequence information alone should be viewed with some skepticism. BioMed Central 2000 2000-11-08 /pmc/articles/PMC138884/ /pubmed/11178260 Text en Copyright © 2000 GenomeBiology.com
spellingShingle Review
Gerlt, John A
Babbitt, Patricia C
Can sequence determine function?
title Can sequence determine function?
title_full Can sequence determine function?
title_fullStr Can sequence determine function?
title_full_unstemmed Can sequence determine function?
title_short Can sequence determine function?
title_sort can sequence determine function?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138884/
https://www.ncbi.nlm.nih.gov/pubmed/11178260
work_keys_str_mv AT gerltjohna cansequencedeterminefunction
AT babbittpatriciac cansequencedeterminefunction

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