Cargando…
The Rab GTPase family
The Rab family is part of the Ras superfamily of small GTPases. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2001
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138937/ https://www.ncbi.nlm.nih.gov/pubmed/11387043 |
_version_ | 1782120528173072384 |
---|---|
author | Stenmark, Harald Olkkonen, Vesa M |
author_facet | Stenmark, Harald Olkkonen, Vesa M |
author_sort | Stenmark, Harald |
collection | PubMed |
description | The Rab family is part of the Ras superfamily of small GTPases. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function as regulators of distinct steps in membrane traffic pathways. In the GTP-bound form, the Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. |
format | Text |
id | pubmed-138937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1389372003-03-03 The Rab GTPase family Stenmark, Harald Olkkonen, Vesa M Genome Biol Protein Family Review The Rab family is part of the Ras superfamily of small GTPases. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function as regulators of distinct steps in membrane traffic pathways. In the GTP-bound form, the Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion. BioMed Central 2001 2001-04-27 /pmc/articles/PMC138937/ /pubmed/11387043 Text en Copyright © 2001 BioMed Central Ltd |
spellingShingle | Protein Family Review Stenmark, Harald Olkkonen, Vesa M The Rab GTPase family |
title | The Rab GTPase family |
title_full | The Rab GTPase family |
title_fullStr | The Rab GTPase family |
title_full_unstemmed | The Rab GTPase family |
title_short | The Rab GTPase family |
title_sort | rab gtpase family |
topic | Protein Family Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138937/ https://www.ncbi.nlm.nih.gov/pubmed/11387043 |
work_keys_str_mv | AT stenmarkharald therabgtpasefamily AT olkkonenvesam therabgtpasefamily AT stenmarkharald rabgtpasefamily AT olkkonenvesam rabgtpasefamily |