Complex genetic diseases: controversy over the Croesus code

The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (S...

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Detalles Bibliográficos
Autores principales: Wright, Alan F, Hastie, Nicholas D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138948/
https://www.ncbi.nlm.nih.gov/pubmed/11532206
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author Wright, Alan F
Hastie, Nicholas D
author_facet Wright, Alan F
Hastie, Nicholas D
author_sort Wright, Alan F
collection PubMed
description The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum).
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spelling pubmed-1389482003-03-03 Complex genetic diseases: controversy over the Croesus code Wright, Alan F Hastie, Nicholas D Genome Biol Opinion The polarization of views on how best to exploit new information from the Human Genome Project for medicine reflects our ignorance of the genetic architecture underlying common diseases: are susceptibility alleles common or rare, neutral or deleterious, few or many? Single-nucleotide polymorphism (SNP) technology is almost in place to dissect such diseases and to create a personalized medicine, but success is critically dependent on the biology and "Nature to be commanded must be obeyed" (Francis Bacon, 1620, Novum Organum). BioMed Central 2001 2001-08-01 /pmc/articles/PMC138948/ /pubmed/11532206 Text en Copyright © 2001 BioMed Central Ltd
spellingShingle Opinion
Wright, Alan F
Hastie, Nicholas D
Complex genetic diseases: controversy over the Croesus code
title Complex genetic diseases: controversy over the Croesus code
title_full Complex genetic diseases: controversy over the Croesus code
title_fullStr Complex genetic diseases: controversy over the Croesus code
title_full_unstemmed Complex genetic diseases: controversy over the Croesus code
title_short Complex genetic diseases: controversy over the Croesus code
title_sort complex genetic diseases: controversy over the croesus code
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138948/
https://www.ncbi.nlm.nih.gov/pubmed/11532206
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