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The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis
A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2001
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138964/ https://www.ncbi.nlm.nih.gov/pubmed/11574063 |
| _version_ | 1782120534315630592 |
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| author | Furley, Andrew J |
| author_facet | Furley, Andrew J |
| author_sort | Furley, Andrew J |
| collection | PubMed |
| description | A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing those genes, enabling the effects of mutations to be observed directly. |
| format | Text |
| id | pubmed-138964 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2001 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-1389642003-03-03 The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis Furley, Andrew J Genome Biol Minireview A key problem in using genetics to dissect the wiring of the mammalian brain lies in discovering which of the billions of neural connections have been disrupted by a particular mutation. A novel gene-trap approach targets the genes involved in brain wiring and labels the axons of neurons expressing those genes, enabling the effects of mutations to be observed directly. BioMed Central 2001 2001-08-29 /pmc/articles/PMC138964/ /pubmed/11574063 Text en Copyright © 2001 BioMed Central Ltd |
| spellingShingle | Minireview Furley, Andrew J The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis |
| title | The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis |
| title_full | The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis |
| title_fullStr | The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis |
| title_full_unstemmed | The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis |
| title_short | The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis |
| title_sort | trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis |
| topic | Minireview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138964/ https://www.ncbi.nlm.nih.gov/pubmed/11574063 |
| work_keys_str_mv | AT furleyandrewj thetrappistsapproachtopathfindingelucidatingbrainwiringusingsecretorytrapmutagenesis AT furleyandrewj trappistsapproachtopathfindingelucidatingbrainwiringusingsecretorytrapmutagenesis |