HIV: master of the host cell

The human immunodeficiency virus has evolved various mechanisms to exploit its host cells, including the interruption and augmentation of signal transduction pathways. Recently, two DNA microarray studies have illustrated a remarkably broad-based perturbation in host transcriptional responses, which...

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Detalles Bibliográficos
Autores principales: Arendt, Christopher W, Littman, Dan R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138982/
https://www.ncbi.nlm.nih.gov/pubmed/11737949
Descripción
Sumario:The human immunodeficiency virus has evolved various mechanisms to exploit its host cells, including the interruption and augmentation of signal transduction pathways. Recently, two DNA microarray studies have illustrated a remarkably broad-based perturbation in host transcriptional responses, which is in part mediated by the HIV-encoded Nef protein. HIV therefore seems to function as a 'master regulator' of cellular gene expression.

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