The evolutionary history of effectors downstream of Cdc42 and Rac

Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests t...

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Detalles Bibliográficos
Autores principales: Cotteret, Sophie, Chernoff, Jonathan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139012/
https://www.ncbi.nlm.nih.gov/pubmed/11864373
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author Cotteret, Sophie
Chernoff, Jonathan
author_facet Cotteret, Sophie
Chernoff, Jonathan
author_sort Cotteret, Sophie
collection PubMed
description Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac.
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spelling pubmed-1390122003-03-03 The evolutionary history of effectors downstream of Cdc42 and Rac Cotteret, Sophie Chernoff, Jonathan Genome Biol Review Cdc42 and Rac - ancient, highly conserved, small GTPases - mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac. BioMed Central 2002 2002-01-14 /pmc/articles/PMC139012/ /pubmed/11864373 Text en Copyright © 2002 BioMed Central Ltd
spellingShingle Review
Cotteret, Sophie
Chernoff, Jonathan
The evolutionary history of effectors downstream of Cdc42 and Rac
title The evolutionary history of effectors downstream of Cdc42 and Rac
title_full The evolutionary history of effectors downstream of Cdc42 and Rac
title_fullStr The evolutionary history of effectors downstream of Cdc42 and Rac
title_full_unstemmed The evolutionary history of effectors downstream of Cdc42 and Rac
title_short The evolutionary history of effectors downstream of Cdc42 and Rac
title_sort evolutionary history of effectors downstream of cdc42 and rac
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139012/
https://www.ncbi.nlm.nih.gov/pubmed/11864373
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